General
Preferred name
FLAVONE
Synonyms
2-PHENYLCHROMONE ()
2-Phenyl-4-benzopyron ()
2-Phenyl-4-chromone ()
2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron ()
Chromocor ()
NSC-19028 ()
Asmacoril ()
2-phenyl-.gamma.-benzopyrone ()
Cromaril ()
Cromarile ()
2-phenyl-1,4-benzopyrone ()
P&D ID
PD002224
CAS
525-82-6
11091-19-3
Tags
available
drug
natural product
obsolete probe
Drug indication
Discovery agent
breast neoplasm
Drug Status
approved
experimental
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Flavone is an endogenous metabolite.
PRICE 29
DESCRIPTION The name 'flavone' is used to refer to the simplest structure within a class of compounds with the backbone structure 2-phenylchromen-4-one, generally referred to as the flavones. (GtoPdb)
DESCRIPTION Flavone (2-Phenyl-4-chromone) have effects on CYP (P450) activity which are enzymes that metabolize most drugs in the body. (TargetMol Bioactive Compound Library)
Cell lines
6
Organisms
2
Compound Sets
15
Cayman Chemical Bioactives
34028
ChEMBL Drugs
CHEMBL275638
CZ-OPENSCREEN Bioactive Library
DrugBank
DB07776
DrugBank Approved Drugs
DB07776
DrugMAP
DMEQH6J
DrugMatrix
Guide to Pharmacology
409
Mcule NIBR MoA Box Subset
MCULE-3856134714
MedChem Express Bioactive Compound Library
HY-N2424
Novartis Chemogenetic Library (NIBR MoA Box)
Obsolete Compounds
flavone
Selleckchem Bioactive Compound Library
flavone
TargetMol Bioactive Compound Library
T2876
The Spectrum Collection
External IDs
39
Properties
(calculated by RDKit )
Molecular Weight
222.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
3.46
TPSA
30.21
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
NOS
Apoptosis
Caspase
CDK
Apoptosis related
Member status
member
MOA
Cytochrome P450 CYP1A1 Inhibitors
Pathway
Immunology/Inflammation
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Source data