General
Preferred name
SALSALATE
Synonyms
Disalicylic acid ()
Salicylsalicylic acid ()
NSC-49171 ()
Sasapyrine ()
NSC-49171,Salsalate ()
Salicylic acid, bimolecular ester ()
Disalicyclic acid ()
Disalcid ()
P&D ID
PD002223
CAS
552-94-3
Tags
prodrug
natural product
drug
available
Approved by
FDA
Drug Status
approved
Drug indication
Analgesic
Rheumatoid arthritis
Anti-Inflammatory
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Compound Sets
19
Cayman Chemical Bioactives
11911
ChEMBL Approved Drugs
CHEMBL154111
ChEMBL Drugs
CHEMBL154111
Drug Repurposing Hub
DrugBank
DB01399
DrugBank Approved Drugs
DB01399
DrugCentral
2420
DrugCentral Approved Drugs
2420
DrugMAP
DM13P4C
DrugMAP Approved Drugs
DM13P4C
DrugMatrix
Ki Database
salsalate
MedChem Express Bioactive Compound Library
HY-B1245
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
sasapyrine
TargetMol Bioactive Compound Library
T0498
The Spectrum Collection
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
258.05
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
2.31
TPSA
83.83
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Immunology/Inflammation
Neuroscience
Metabolic Enzyme/Protease
NF-κB
Target
COX-1
COX-2
PTGS1, PTGS2
Reactive Oxygen Species
Immunology & Inflammation related
Member status
member
MOA
inhibition of p300-induced Tau acetylation
Non-Steroidal Antiinflammatory Drugs
NF-kappaB (NFKB) Activation Inhibitors
NFkB pathway inhibitor
Indication
osteoarthritis, rheumatoid arthritis
Therapeutic Class
Antiinflammatory Agents
Source data