General
Preferred name
XANTHONE
Synonyms
Xanthone (Genicide) ()
Genicide ()
9H-xanthen-9-one ()
P&D ID
PD002208
CAS
90-47-1
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 ¦ÌM. Xanthon inhibits Norepinephrine (HY-13715) and high-K+-induced vasoconstriction with IC50 values of 60.26 ¦ÌM and 82.9 ¦ÌM, respectively. Xanthon increases intracellular cyclic adenosine 3¡ä,5¡ä-monophosphate (cAMP) content and blocks Ca2+ channels. Xanthone is the scaffold of several pharmacologically active compounds[1][2].
PRICE 29
DESCRIPTION Xanthone (Xanthenone) is currently used as ovicide for codling moth eggs and as a larvicide.
DESCRIPTION Xanthone is a polyketide synthase-derived xanthone, isolated from Mangosteen. It has anti-bacterial, anti-fungal, anti-inflammatory, and anti-viral activities. Xanthone is an activator of Protein kinase C zeta type. (Enamine Bioactive Compounds)
DESCRIPTION Concentration required to inhibit monoamine oxidase activity by 50% (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
9
AdooQ Bioactive Compound Library
A10993
Cayman Chemical Bioactives
34098
Drug Repurposing Hub
Enamine Bioactive Compounds
EBC-13728
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-N0126
Selleckchem Bioactive Compound Library
Xanthone(Genicide)
TargetMol Bioactive Compound Library
N105-0092
The Spectrum Collection
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
196.05
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
3
cLogP
2.95
TPSA
30.21
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
antimalarial agent
Target
Calcium Channel
Monoamine Oxidase
ADC Cytotoxin
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data