General
Preferred name
APIGENIN
Synonyms
4',5,7-Trihydroxyflavone ()
Apigenol ()
C.I. Natural Yellow 1 ()
NSC 83244 ()
Apigenin (LY 080400) ()
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one ()
Apigenin-d5 ()
P&D ID
PD002200
CAS
520-36-5
461015-54-3
263711-74-6
Tags
available
drug candidate
natural product
nuisance
obsolete probe
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Apigenin is a plant-derived flavonoid. It has been found in coriander, celery and chili peppers.
(GtoPdb)
DESCRIPTION
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 ¦ÌM.
PRICE
29
DESCRIPTION
Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing qualities as a sedative, mild analgesic and sleep medication. Apigenin has not been implicated in causing serum enzyme elevations or clinically apparent liver injury.
DESCRIPTION
Inhibits RNA polymerase
(Tocris Bioactive Compound Library)
DESCRIPTION
Arrests cell cycle at G2/M phase
(LOPAC library)
DESCRIPTION
Protein kinase inhibitor
(Tocriscreen Total)
DESCRIPTION
Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (Ki= 0.74 µM). It also inhibits cytochrome P450s and BACE-1.
(Enamine Bioactive Compounds)
DESCRIPTION
Activity at soybean LOX-1 using linoleic acid as substrate at 100 uM preincubated for 5 mins followed by substrate addition by Michaelis-Menten plot analysis; Inhibition of AChE (unknown origin); Inhibition of human CYP1B1 by EROD assay; PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of glucocorticoid receptor signaling. (Class of assay: confirmatory)
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
17
Organisms
13
Compound Sets
23
AdooQ Bioactive Compound Library
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
IPPI - DB
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
Obsolete Compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
53
Molecular Weight
270.05
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.58
TPSA
90.9
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
4
aggregator (Aggregator Advisor)
Aggregators
historic compounds (Chemical Probes.org)
Obsolete
aggregator (ZINC)
Aggregators
Nonspecific/NOS
Flavonoid
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Broad Spectrum Protein Kinase Inhibitors
MOA
Inhibitor
casein kinase inhibitor, cell proliferation inhibitor
Target
AKR1B1, AR, CDK6, CFTR, CYP19A1, CYP1B1, HSD17B1
Autophagy
Cytochrome P450
Endogenous Metabolite
P450 (e.g. CYP17)
Pathway
Metabolic Enzyme/Protease
Source data
