General
Preferred name
EPICATECHIN
Synonyms
(-)-Epicatechol ()
L-Epicatechin ()
(-)-EPICATECHIN ()
(-)-Epicatechin(-)-Epicatechol ()
EPICATECHIN, (-) ()
epi-Catechin ()
L-Epicatechin, (-)-Epicatechol ()
(-)Epicatechin ()
Epi-catechol ()
L-acacatechin ()
NSC-81161 ()
(-)-epi catechin ()
Epicatechol ()
P&D ID
PD002152
CAS
490-46-0
2545-08-6
17334-50-8
Tags
available
drug candidate
natural product
nuisance
Drug indication
Pulmonary arterial hypertension
Friedreich's ataxia
Duchenne dystrophy
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 ¦ÌM. (-)-Epicatechin inhibits the IL-1¦Â-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-¦ÊB.
PRICE
44
DESCRIPTION
(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1??-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-??B.
DESCRIPTION
(-)-Epicatechin is a natural bitter-tasting compound that is present in plants such as Visnea mocanera and Litsea rotundifolia.
Preliminary evidence suggests that it behaves as a β-arrestin-biased agonist at the apelin receptor, with no effect on forskolin-stimulated cAMP production . (GtoPdb)
Preliminary evidence suggests that it behaves as a β-arrestin-biased agonist at the apelin receptor, with no effect on forskolin-stimulated cAMP production . (GtoPdb)
DESCRIPTION
(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
14
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
290.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
5
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
1.55
TPSA
110.38
Fraction CSP3
0.2
Chiral centers
2.0
Largest ring
6.0
QED
0.51
Structural alerts
1
Nonspecific/NOS
IMP
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
COX
Endogenous Metabolite
Ferroptosis
antioxidant
Pathway
Apoptosis
Immunology/Inflammation
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Source data
