General
Preferred name
Epigallocatechin gallate
Synonyms
epigallocatechin-3-monogallate ()
EGCG ()
Epigallocatechol Gallate ()
(-)-Epigallocatechin Gallate ()
PMID26394986-Compound-44 ()
PMID26560530-Compound-26 ()
Epigallocatechin gallate989-51-5 ()
EPIGALOCATECHIN GALLATE ()
epigallocatechin-3-gallate ()
(-)-Epigallocatechin Gallate-d3/d4 ()
Epigallocatechin-3-gallate (ECGC) ()
P&D ID
PD002148
CAS
989-51-5
863-65-0
Tags
available
drug candidate
natural product
nuisance
obsolete probe
Drug indication
Barrett's esophagus
Hepatic fibrosis
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Epigallocatechin-3-gallate (EGCG) is one of the catechins that are found in green tea. It had been ascribed activity as a histone acetyltransferase (HAT) inhibitor. However, a 2017 article by Dahlin et al. suggests that the thiol-reactivity of EGCG brings in to question its activity as a HAT inhibitor . Amongst the plethora of health benefits attributed to the catechins, EGCG has demonstrated antibacterial activity and broad-spectrum antiviral activity .
SARS-CoV-2 and COVID-19: In relation to SARS-CoV-2, molecular docking analysis suggests that EGCG interacts with the virus' S protein and main protease (Mpro; 3CLpro) . Evidence also suggests that catechins bind to the S1 ubiquitin-binding site of the virus' second protease PLPro. It is hypothesised that inhibiting PLPro will reduce the enzyme's inhibitory function on the host ubiquitin proteasome and interferon stimulated gene systems, thus targeting some of the inflammatory aspects of SARS-CoV-2 infection. (GtoPdb)
SARS-CoV-2 and COVID-19: In relation to SARS-CoV-2, molecular docking analysis suggests that EGCG interacts with the virus' S protein and main protease (Mpro; 3CLpro) . Evidence also suggests that catechins bind to the S1 ubiquitin-binding site of the virus' second protease PLPro. It is hypothesised that inhibiting PLPro will reduce the enzyme's inhibitory function on the host ubiquitin proteasome and interferon stimulated gene systems, thus targeting some of the inflammatory aspects of SARS-CoV-2 infection. (GtoPdb)
PRICE
29
DESCRIPTION
(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma[1][2][3][4].
DESCRIPTION
natural product
(Informer Set)
DESCRIPTION
Potent and selective PDE4 inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
(-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
28
Organisms
11
Compound Sets
21
A Collection of Useful Nuisance Compounds (CONS) for Interrogation of Bioassay Integrity
AdooQ Bioactive Compound Library
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
Guide to Pharmacology
Informer Set
LINCS compound set
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Nuisance compounds in cellular assays
Obsolete Compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
62
Molecular Weight
458.08
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
8
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
2.23
TPSA
197.37
Fraction CSP3
0.14
Chiral centers
2.0
Largest ring
6.0
QED
0.21
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific reactivity
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Compound status
probe
Pathway
NF-¦ÊB
Apoptosis
Autophagy
Immunology/Inflammation
Metabolism
Microbiology/virology
NF-κB
Proteases/Proteasome
Metabolic Enzyme/Protease
Primary Target
Other Proteases
MOA
Inhibitor
bacterial DNA gyrase inhibitor
Target
ELANE, EP300, FASN, KAT2B, MMP14, MMP2
Endogenous Metabolite
DNA Methyltransferase,EGFR,Fatty Acid Synthase,HER2,Telomerase
Ferroptosis
HIV
Mitochondrial Metabolism
Reactive Oxygen Species
Nuisance MOA
catechol
Targets
Enoyl-acyl-carrier protein reductase
CpG DNA methylase
Fatty acid synthase
Source data
