General
Preferred name
dantron
Synonyms
DANTHRON ()
1,8-Dihydroxyanthraquinone ()
NSC7210 ()
Chrysazin ()
Antrapurol ()
chrysazin, Antrapurol ()
Dantrone ()
NSC-646568 ()
NSC-38626 ()
Dantron ()
Istizin ()
Dorbane ()
Pilules vinchy n.f. ()
P&D ID
PD002124
CAS
117-10-2
Tags
available
drug
Approved by
MHRA
First approval
1994
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Drug indication
Constipation
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
PRICE 29
DESCRIPTION Danthron (Antrapurol) is a natural product, regulates glucose, and lipid metabolism by activating AMPK. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
18
Bioprocess diversity set
ChEMBL Approved Drugs
CHEMBL53418
ChEMBL Drugs
CHEMBL53418
Drug Repurposing Hub
DrugBank
DB04816
DrugBank Approved Drugs
DB04816
DrugCentral
3125
DrugCentral Approved Drugs
3125
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL53418
MedChem Express Bioactive Compound Library
HY-B0923
NIH Mechanistic Set
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
danthron
TargetMol Bioactive Compound Library
T0800
The Spectrum Collection
Withdrawn 2.0
w108
External IDs
39
Properties
(calculated by RDKit )
Molecular Weight
240.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
2
cLogP
1.87
TPSA
74.6
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
1
quinone_A(370)
[!#6&!#1]=[#6]1[#6]=,:[#6][#6](=[!#6&!#1])[#6]=,:[#6]1
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Biological process
Cell polarity & morphogenesis
MOA
laxative
ATC
A06AB53
Toxicity type
carcinogenicity
Pathway
Autophagy
Chromatin/Epigenetic
Microbiology/virology
PI3K/Akt/mTOR signaling
Anti-infection
Epigenetics
PI3K/Akt/mTOR
Target
AMPK
Bacterial
Virus Protease
Source data