General
Preferred name
TROPICAMIDE
Synonyms
Ro 1-7683 ()
NSC-757372 ()
Bistropamide ()
Nods ()
Tropicamidum ()
Visumidriatic ()
Mydriafair ()
RO-1-7683 ()
Tropicacyl ()
Mydriacyl ()
P&D ID
PD002097
CAS
1508-75-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1960
Drug Status
investigational
approved
Drug indication
Anticholinergic
Mydriasis
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tropicamide is an antimuscarinic drug. (GtoPdb)
DESCRIPTION M4 muscarinic acetylcholine receptor antagonist (LOPAC library)
DESCRIPTION Selective M4 muscarinic antagonist (Tocriscreen Plus)
DESCRIPTION 5-HT1A and 5-HT1B agonist (Tocris Bioactive Compound Library)
DESCRIPTION Selective M4 muscarinic antagonist (Tocriscreen Total)
Compound Sets
28
AdooQ Bioactive Compound Library
A11706
ChEMBL Approved Drugs
CHEMBL1200604
ChEMBL Drugs
CHEMBL1200604
Concise Guide to Pharmacology 2021/22
7319
Concise Guide to Pharmacology 2023/24
7319
DrugBank
DB00809
DrugBank Approved Drugs
DB00809
DrugCentral
2774
DrugCentral Approved Drugs
2774
DrugMAP
DM1D90W
DrugMAP Approved Drugs
DM1D90W
DrugMatrix
Guide to Pharmacology
7319
Ki Database
TROPICAMIDE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200604
NCATS Inxight Approved Drugs
N0A3Z5XTC6
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
tropicamide
TargetMol Bioactive Compound Library
T1281
The Spectrum Collection
Tocris Bioactive Compound Library
0909
Tocriscreen Plus
0909
Tocriscreen Total
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
284.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.21
TPSA
53.43
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
M4
Pathway
Neuroscience
Target
M4 mAChR
AChR
Primary Target
M4 Receptors
MOA
Antagonist
CHRM4 antagonist
Anticholinergics
CHRM4 Antagonists
Member status
member
Therapeutic Class
Diagnostic Agents
Source data