General
Preferred name
TROPICAMIDE
Synonyms
Ro 1-7683 ()
TROPICACYL ()
TROPICAMIDUM ()
NODS ()
Tropicamide component of mydcombi ()
NSC-757372 ()
Tropicamide component of paremyd ()
TROPICAMIDA ()
VISUMIDRIATIC ()
MYDRIAFAIR ()
MYDRIACYL ()
BISTROPAMIDE ()
RO-1-7683 ()
TROPICAMIDE COMPONENT OF MYDCOMBI ()
TROPICAMIDE COMPONENT OF PAREMYD ()
P&D ID
PD002097
CAS
1508-75-4
Tags
available
drug
Approved by
FDA
First approval
1960
Drug indication
Mydriasis
eye disease
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Tropicamide is an antimuscarinic drug.
(GtoPdb)
DESCRIPTION
M4 muscarinic acetylcholine receptor antagonist
(LOPAC library)
DESCRIPTION
Selective M4 muscarinic antagonist
(Tocriscreen Plus)
DESCRIPTION
Selective M4 muscarinic antagonist
(Tocriscreen Total)
DESCRIPTION
Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with anticholinergic properties similar to atropine. Upon ocular administration, it binds to and blocks muscarinic receptors in the sphincter and ciliary muscles, inhibiting cholinergic responses and causing pupil dilation and ciliary muscle paralysis. Tropicamide is used as a diagnostic agent to induce short-duration mydriasis and cycloplegia.
(TargetMol Bioactive Compound Library)
DESCRIPTION
5-HT1A and 5-HT1B agonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
29
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
EUbOPEN Chemogenomics Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
284.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.21
TPSA
53.43
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
M4
Target
M4 mAChR
mAChR
AChR
Primary Target
M4 Receptors
MOA
Antagonist
CHRM4 antagonist
Anticholinergics
CHRM4 Antagonists
Member status
member
Pathway
Neuroscience
Therapeutic Class
Diagnostic Agents
Recommended Cell Concentration
10 uM
Source data
