General
Preferred name
TRYPTOPHAN
Synonyms
TRYPTOPHAN (L) ()
L-tryptophan ()
(±)-Tryptophan ()
(S)-Tryptophan ()
L-Tryptophane ()
Tryptophane ()
L-Tryptophane(S)-Tryptophan ()
L-Trypthophane ()
DL-TRYPTOPHAN ()
Tryptophan, l- ()
Trytophan- ()
NSC-13119 ()
(-)-tryptophan ()
Optimax Wv ()
Gppe Pdr Sach ()
Optimax ()
Tryptophan ((-),l,s) ()
Pacitron ()
L-Tryptophan ()
Triptofano ()
L-Tryptophan-d5 ()
P&D ID
PD002096
CAS
73-22-3
6912-86-3
54-12-6
62595-11-3
Tags
available
drug
Approved by
FDA
Drug indication
male breast carcinoma
Depression
Drug Status
approved
withdrawn
nutraceutical
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
L-Tryptophan (Tryptophan) is an orally active and essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. L-Tryptophan can promote an increase in stemness and osteogenic ability of BMSCs in vitro and in vivo. L-Tryptophan inhibits cell proliferation and induced cell cycle arrest with high levels[1][2][3].
PRICE
29
DESCRIPTION
DL-Tryptophan ((??)-Tryptophan) containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Low thalamic Tryptophan uptake appears to be a strong, independent predictor of long survival in patients with previous glioma treatment.
DESCRIPTION
Antidepressant; precursor of serotonin
(LOPAC library)
DESCRIPTION
L-Tryptophan is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3. It acts like a natural mood regulator that is necessary for normal growth in infants and for nitrogen balance in adults. L-Tryptophan may be useful in increasing serotonin production, promoting healthy sleep, managing depression by enhancing mental and emotional well-being, managing pain tolerance, and managing weight.
(Enamine Bioactive Compounds)
DESCRIPTION
DL-Tryptophan ((±)-Tryptophan) containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Low thalamic Tryptophan uptake appears to be a strong, independent predictor of long survival in patients with previous glioma treatment.
(TargetMol Bioactive Compound Library)
DESCRIPTION
L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid) and of INDOLE ALKALOIDS in plants. It can be a precursor to NIACIN, although inefficiently in mammals.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
25
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
66
Molecular Weight
204.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.12
TPSA
79.11
Fraction CSP3
0.18
Chiral centers
1.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Human Endogenous Metabolite
serotonin
Amino Acids and Derivatives
Endogenous Metabolite
CASR, IDO1, SLC36A1, WARS, WARS2
Indication
anxiety, bloating, constipation, fatigue, sleeplessness
Disease Area
neurology/psychiatry, gastroenterology
MOA
serotonin receptor partial agonist
ATC
N06AX02
Toxicity type
hematological
Therapeutic Class
Antidepressants
Pathway
Metabolism
Neuroscience
Source data
