General
Preferred name
UREA
Synonyms
Carbamide peroxide ()
Carbonyldiamide ()
carbamide ()
E-Cardamoni ()
Ureophil ()
UREA C 14 ()
UREA C-13 ()
Urea C-14 ()
UREA C 13 ()
Carbonyl diamide ()
Carbonyldiamide, Ureophil ()
Nutraplus ()
Sential E ()
Sterile Urea ()
E-927A ()
E927b ()
Aquadrate ()
Calmurid ()
INS NO.927A ()
Flexifoot ()
Eucerin ()
NSC-34375 ()
Ureaphil ()
Hydromol Intensive ()
Azodicarboxylic acid-diamide ()
St.James Balm ()
Flexitol ()
INS-927A ()
Balneum Plus ()
Urea-14c ()
Pytest Kit ()
Carbon 14 urea ()
Carbon-14 urea ()
Urea (14C) ()
Pytest ()
14c-urea ()
Urea, c-14 ()
Urea ((sup 14)c) ()
Urea 14 c ()
Urea (13C) ()
13-c-urea ()
Pylori-Chek Breath Test ()
Urea 13 c ()
Meretek Ubt Kit (W/ Pranactin) ()
Breathtek Ubt For H-Pylori ()
13-c urea ()
Urea ((sup 13)c) ()
Carbon-13 urea ()
Helicosol ()
(13c) urea ()
13c-urea ()
Urea, c-13 ()
Carbone (13) urea ()
P&D ID
PD002093
CAS
57-13-6
58069-82-2
30535-50-3
173144-80-4
37955-36-5
12263-76-2
594-05-8
Tags
available
drug
Approved by
EMA
FDA
First approval
1966
1996
1997
Drug Status
investigational
approved
Drug indication
Dermatological disease
Diuretic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA The urease enzyme is not present in mammalian cells, so the presence of urease in the stomach is evidence that bacteria are present. The presence of urease is not specific for H. pylori, but other bacteria are not usually found in the stomach. To detect H. pylori, urea labeled with 14C is swallowed by the patient. If gastric urease from H. pylori is present, urea is split to form CO2 and NH3 at the interface between the gastric epithelium and lumen and 14CO2 is absorbed into the blood and exhaled in the breath.; Following ingestion of the capsule by a patient with H. pylori, 14CO2 excretion in the breath peaks between 10 and 15 minutes and declines thereafter with a biological half-life of about 15 minutes. Therefore, the detection of isotope-labelled carbon dioxide in exhaled breath indicates that urease is present in the stomach, and hence that H. pylori bacteria are present.
INDICATION Indicated as a dental bleaching agent. ; ; Indicated as an oral wound healing agent in oral mucosal injuries.; ; Indicated as an aid in the removal of hardened ear wax.
INDICATION
  • ;
  • 10% hydrate skin
  • ;
  • 15% accelerate fibrin degradation
  • ;
  • 20-30% are antipruritic, break down keratin, decrease the thickness of the stratum corneum and are used in scaling conditions such as ichthysosis
  • ;
  • 40% are proteolytic and may be used to dissolve and peel dystrophic nails
  • ;
;
[Patient Self Care, 2010]
Compound Sets
21
ChEMBL Approved Drugs
CHEMBL985
CHEMBL2096635
CHEMBL2096648
ChEMBL Drugs
CHEMBL985
CHEMBL2096635
CHEMBL2096648
Concise Guide to Pharmacology 2017/18
4539
Concise Guide to Pharmacology 2019/20
4539
Concise Guide to Pharmacology 2021/22
4539
Concise Guide to Pharmacology 2023/24
4539
Drug Repurposing Hub
DrugBank
DB03904
DB09513
DB09510
DB11129
DrugBank Approved Drugs
DB03904
DB09513
DB09510
DB11129
DrugCentral
4264
5147
4323
DrugCentral Approved Drugs
4264
5147
4323
DrugMAP
DMUK75B
DrugMAP Approved Drugs
DMUK75B
DrugMatrix
Guide to Pharmacology
4539
MedChem Express Bioactive Compound Library
HY-Y0271
NCATS Inxight Approved Drugs
W6KX9E6D8X
WBZ6M63TEE
ReFrame library
Selleckchem Bioactive Compound Library
urea
TargetMol Bioactive Compound Library
T0738
The Spectrum Collection
External IDs
95
Properties
(calculated by RDKit )
Molecular Weight
60.03
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.98
TPSA
69.11
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cytoskeletal Signaling
Metabolism
Immunology/Inflammation
Stem Cells
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Metabolic Enzyme/Protease
Target
Arginase-1
Carbonic anhydrase II
DHFR
Sulfoxide reductase catalytic subunit YedY
Wnt/??-catenin
ARG1, CA2, CTNNB1
Endogenous Metabolite
Indication
psoriasis, xerosis cutis, ichthyosis vulgaris, eczema, keratosis, dermatitis
MOA
hydroxy radical formation stimulant
Source data