General
Preferred name
UREA
Synonyms
Carbamide peroxide ()
Ureophil ()
carbamide ()
E-Cardamoni ()
Carbonyldiamide ()
UREA C 14 ()
UREA C-13 ()
Urea C-14 ()
Carbonyldiamide, Ureophil ()
Carbonyl diamide ()
Ureaphil ()
Hydromol Intensive ()
Nutraplus ()
Sterile Urea ()
Azodicarboxylic acid-diamide ()
Eucerin ()
Urea component of u-cort ()
INS-927A ()
Urea component of carmol hc ()
Urea component of alphaderm ()
Flexifoot ()
INS NO.927A ()
E-927A ()
Balneum Plus ()
Aquadrate ()
St.James Balm ()
Urea component of calmurid hc ()
Calmurid ()
E927b ()
Flexitol ()
Sential E ()
NSC-34375 ()
14c-urea ()
Carbon 14 urea ()
Urea (14C) ()
Urea ((sup 14)c) ()
Urea, c-14 ()
Carbon-14 urea ()
Pytest Kit ()
Urea 14 c ()
Urea-14c ()
Pytest ()
Urea ((sup 13)c) ()
Pylobactell ()
Breathtek Ubt For H-Pylori ()
13c-urea ()
(13c) urea ()
Urea 13 c ()
Meretek Ubt Kit (W/ Pranactin) ()
Urea, c-13 ()
Urea (13C) ()
Pylori-chek ()
Helicosol ()
Helicobacter test infai ()
Pylori-Chek Breath Test ()
13-c-urea ()
Carbon-13 urea ()
Carbone (13) urea ()
13-c urea ()
UREA C 13 ()
P&D ID
PD002093
CAS
57-13-6
58069-82-2
30535-50-3
173144-80-4
37955-36-5
12263-76-2
594-05-8
Tags
available
drug
Approved by
FDA
EMA
First approval
1966
1997
1996
1982
Drug indication
Helicobacter pylori infectious disease
infection
Dermatological disease
Skin disease
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
  • ;
  • 10% hydrate skin
  • ;
  • 15% accelerate fibrin degradation
  • ;
  • 20-30% are antipruritic, break down keratin, decrease the thickness of the stratum corneum and are used in scaling conditions such as ichthysosis
  • ;
  • 40% are proteolytic and may be used to dissolve and peel dystrophic nails
  • ;
;
[Patient Self Care, 2010]
DESCRIPTION Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
PRICE 29
MOA The urease enzyme is not present in mammalian cells, so the presence of urease in the stomach is evidence that bacteria are present. The presence of urease is not specific for H. pylori, but other bacteria are not usually found in the stomach. To detect H. pylori, urea labeled with 14C is swallowed by the patient. If gastric urease from H. pylori is present, urea is split to form CO2 and NH3 at the interface between the gastric epithelium and lumen and 14CO2 is absorbed into the blood and exhaled in the breath.; Following ingestion of the capsule by a patient with H. pylori, 14CO2 excretion in the breath peaks between 10 and 15 minutes and declines thereafter with a biological half-life of about 15 minutes. Therefore, the detection of isotope-labelled carbon dioxide in exhaled breath indicates that urease is present in the stomach, and hence that H. pylori bacteria are present.
INDICATION Indicated as a dental bleaching agent. ; ; Indicated as an oral wound healing agent in oral mucosal injuries.; ; Indicated as an aid in the removal of hardened ear wax.
DESCRIPTION Urea is a compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. It is a keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin. (Enamine Bioactive Compounds)
DESCRIPTION Urea (Carbonyldiamide) is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for about one-half of the total urinary solids. (TargetMol Bioactive Compound Library)
Compound Sets
23
ChEMBL Approved Drugs
CHEMBL985
CHEMBL2096635
CHEMBL2096648
ChEMBL Drugs
CHEMBL985
CHEMBL2096635
CHEMBL2096648
Concise Guide to Pharmacology 2017/18
4539
Concise Guide to Pharmacology 2019/20
4539
Concise Guide to Pharmacology 2021/22
4539
Concise Guide to Pharmacology 2023/24
4539
Concise Guide to Pharmacology 2025/26
4539
Drug Repurposing Hub
DrugBank
DB03904
DB09513
DB09510
DB11129
DrugBank Approved Drugs
DB03904
DB09513
DB09510
DB11129
DrugCentral
4264
5147
4323
DrugCentral Approved Drugs
4264
5147
4323
DrugMAP
DMUK75B
DrugMAP Approved Drugs
DMUK75B
DrugMatrix
Enamine Bioactive Compounds
EBC-03021
Guide to Pharmacology
4539
MedChem Express Bioactive Compound Library
HY-Y0271
NCATS Inxight Approved Drugs
W6KX9E6D8X
WBZ6M63TEE
ReFrame library
Selleckchem Bioactive Compound Library
urea
TargetMol Bioactive Compound Library
T0738
The Spectrum Collection
External IDs
185
Properties
(calculated by RDKit )
Molecular Weight
60.03
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.98
TPSA
69.11
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Arginase-1
Carbonic anhydrase II
DHFR
Endogenous Metabolite
Sulfoxide reductase catalytic subunit YedY
Wnt/β-catenin
ARG1, CA2, CTNNB1
Apoptosis
Carbonic Anhydrase
Environmental Pollutants
ERK
Indication
psoriasis, xerosis cutis, ichthyosis vulgaris, eczema, keratosis, dermatitis
MOA
hydroxy radical formation stimulant
Pathway
Cell Cycle/Checkpoint
Cytoskeletal Signaling
DNA Damage/DNA Repair
Immunology/Inflammation
Metabolism
Stem Cells
MAPK/ERK Pathway
Metabolic Enzyme/Protease
Stem Cell/Wnt
Source data