General
Preferred name
VALPROATE SODIUM
Synonyms
Valproic acid, sodium salt ()
Valproic acid sodium ()
Sodium Valproate ()
Valproic acid sodium salt ()
Valproic acid (sodium) ()
Sodium Valproate (sodium) ()
Valproic Acid (NSC 93819) sodium salt ()
Sodium valproate,NSC 93819,2-Propylpentanoic Acid ()
Epilim Chronosphere ()
NSC-732626 ()
Selenica ()
A-44090 ()
ABBOTT 44090 ()
Depakote ()
Epilim IV ()
Epilim Chrono 200 ()
Epilim Chrono 300 ()
NSC-757376 ()
KW-6066N ()
Valproic acid, sodium ()
Orlept ()
Valproic acid sodium salt (1:1) ()
Depakote CP ()
Sodium 2-propylpentanoate ()
Delepsine ()
Epilim ()
Epilim 200 ()
Orfiril ()
ABBOTT-44090 ()
Episenta ()
Natrii valproas ()
Depakote Er ()
Epilim 500 ()
Depakine ()
Epilim Chrono 500 ()
Kentilim ()
Depacon ()
Valproic acid (sodium salt) ()
P&D ID
PD002091
CAS
1069-66-5
99-66-1
Tags
natural product
drug
available
Drug indication
Anticonvulsant
Discovery agent
Drug Status
approved
Max Phase
Phase 4
First approval
1996
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Anticonvulsant
(LOPAC library)
DESCRIPTION
Histone deacetylase inhibitor
(Tocriscreen Plus)
DESCRIPTION
Protein tyrosine phosphatase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Valproic acid is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugMAP
LOPAC library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
166.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-2.04
TPSA
40.13
Fraction CSP3
0.88
Chiral centers
0.0
Largest ring
0.0
QED
0.44
QED
0.44
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Chromatin/Epigenetic
Membrane Transporter/Ion Channel
DNA Damage/DNA Repair
Neuroscience
NF-??b
Anti-infection
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Epigenetics
Metabolic Enzyme/Protease
Neuronal Signaling
Stem Cell/Wnt
Target
GABAR
HDAC2
HDAC9
Anti-convulsant
Endogenous Metabolite
HDAC
HIV
Mitophagy
Notch
Autophagy,GABA Receptor,HDAC,Mitophagy,Notch,PGC-1¦Á
Primary Target
Non-selective HDACs
MOA
Inhibitor
Solubility
In vitro:<br/>10 mM in DMSO
Source data
