General
Preferred name
ARBUTIN
Synonyms
¦Á-Arbutin ()
¦Â-Arbutin ()
β-Arbutin ()
p-Arbutin ()
Uva, Ursi, p-Arbutin, Hydroquinone β-D-glucopyranoside ()
??Arbutin ()
Uva, Ursi, p-Arbutin, Hydroquinone ??D-glucopyranoside ()
Uva,p-Arbutin, ¦Â-Arbutin ()
NSC-4036 ()
Arbutinum ()
Ursin ()
Arbutoside ()
Arbutin-d4 ()
P&D ID
PD002012
CAS
497-76-7
Tags
available
prodrug
drug
Approved by
FDA
Drug Status
approved
investigational
Max Phase
2.0
Drug indication
freckles
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Arbutin (¦Â-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].
PRICE 29
DESCRIPTION Arbutin (p-Arbutin)(??-Arbutin) is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos and can inhibit tyrosinase and thus prevent the formation of melanin.
DESCRIPTION Arbutin (p-Arbutin)(β-Arbutin) is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos and can inhibit tyrosinase and thus prevent the formation of melanin. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
12
AdooQ Bioactive Compound Library
A10084
Cayman Chemical Bioactives
26407
33289
ChEMBL Drugs
CHEMBL232202
Drug Repurposing Hub
DrugBank
DB11217
DrugBank Approved Drugs
DB11217
DrugCentral
4267
DrugCentral Approved Drugs
4267
MedChem Express Bioactive Compound Library
HY-N0192
Selleckchem Bioactive Compound Library
Arbutin(Uva,-p-Arbutin)
TargetMol Bioactive Compound Library
T0473
The Spectrum Collection
External IDs
54
Properties
(calculated by RDKit )
Molecular Weight
272.09
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
5
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
-1.43
TPSA
119.61
Fraction CSP3
0.5
Chiral centers
5.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Tyrosinase
TYR
Endogenous Metabolite
MOA
melanin inhibitor
Pathway
Metabolic Enzyme/Protease
Proteases/Proteasome
Source data