General
Preferred name
PHLORIZIN
Synonyms
PHLORIDZIN ()
Floridzin ()
NSC 2833 ()
Phloridzin dihydrate ()
Phlorizin (Phloridzin) ()
PHLORIZINE ()
Phlorizin dihydrate ()
P&D ID
PD002007
CAS
60-81-1
112318-65-7
7061-54-3
Tags
available
drug candidate
natural product
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Found in the bark of several types of fruit tree. Within the body, phlorizin is converted into (which also occurs naturally) by hydrolytic enzymes.
(GtoPdb)
PRICE
29
DESCRIPTION
Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
PRICE
29
DESCRIPTION
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
(TargetMol Bioactive Compound Library)
DESCRIPTION
1. Phlorizin dihydrate (Phloridzin dihydrate) can significantly inhibit oxidative DNA damage.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
19
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
59
Molecular Weight
436.14
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
7
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.2
TPSA
177.14
Fraction CSP3
0.38
Chiral centers
5.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Hsglt1
hSGLT2
Na+/K+ ATPase
SGLT
SLC5A1, SLC5A11, SLC5A2, SLC5A3
ATPase,SGLT
Pathway
DNA Damage/DNA Repair
Membrane Transporter/Ion Channel
GPCR/G protein
Member status
member
MOA
SGLT-1 Inhibitors
SGLT-2 Inhibitors
sodium/glucose cotransporter inhibitor
Source data
