General
Preferred name
PHLORACETOPHENONE
Synonyms
2,4,6-TRIHYDROXYACETOPHENONE ()
1-(2,4,6-Trihydroxyphenyl)ethanone ()
Monoacetylphloroglucinol (hydrate) ()
Monoacetylphloroglucinol ()
P&D ID
PD001997
CAS
480-66-0
249278-28-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7¦Á-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].
PRICE 29
DESCRIPTION Phloracetophenone (1-(2,4,6-Trihydroxyphenyl)ethanone) has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity. (TargetMol Bioactive Compound Library)
DESCRIPTION Phloracetophenone is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. It exhibits a broad range of antibiotic activity. Phloracetophenone also inhibits phospholipase A2. (Enamine Bioactive Compounds)
Cell lines
2
Organisms
0
Compound Sets
6
Cayman Chemical Bioactives
19451
Enamine Bioactive Compounds
EBC-249104
MedChem Express Bioactive Compound Library
HY-W008226
Selleckchem Bioactive Compound Library
phloracetophenone
TargetMol Bioactive Compound Library
T2840
The Spectrum Collection
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
168.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
1.01
TPSA
77.76
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.55
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
Cytochrome P450
P450 (e.g. CYP17)
Pathway
Metabolism
Microbiology/virology
Anti-infection
Metabolic Enzyme/Protease
Source data