General
Preferred name
ISONIAZID
Synonyms
PASINIAZID ()
Isonicotinic acid hydrazide ()
Isonicotinic hydrazide ()
INH ()
Isoniazid54-85-3 ()
Cotinazin ()
Hyzyd ()
Nicotibine ()
Hidrasonil ()
Dow-Isoniazid ()
Dianicotyl ()
Ipcazide ()
Isonicotinylhydrazine ()
Ertuban ()
Isoniazidum ()
Neumandin ()
Rimifon ()
Hydrazid ()
Cedin ()
Isidrina ()
Mybasan ()
Isobicina ()
Tisiodrazida ()
Armazid ()
Iscotin ()
Isonicotan ()
Nydrazid ()
Atcotibine ()
NSC-9659 ()
Armazide ()
Eralon ()
Laniazid ()
Stanozide ()
Teebaconin ()
P&D ID
PD001926
CAS
54-85-3
37271-10-6
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1952
Drug Status
investigational
approved
Drug indication
Tuberculosis
Antibacterial (tuberculostatic)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Isoniazid is an antimycobacterial drug used in the treatment of tuberculosis (TB) . Functionally, it inhibits the synthesis of mycolic acid, an essential component of the mycobacterial cell wall . (GtoPdb)
PHARMACODYNAMICS Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. It is a highly specific agent, ineffective against other microorganisms. Isoniazid is bactericidal when mycobacteria grow rapidly and bacteriostatic when they grow slowly.
Cell lines
3
Organisms
4
Compound Sets
24
Cayman Chemical Bioactives
20378
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL64
ChEMBL Drugs
CHEMBL64
Drug Repurposing Hub
DrugBank
DB00951
DrugBank Approved Drugs
DB00951
DrugCentral
1497
DrugCentral Approved Drugs
1497
DrugMAP
DM5JVS3
DrugMAP Approved Drugs
DM5JVS3
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
12761
MedChem Express Bioactive Compound Library
HY-B0329
NCATS Inxight Approved Drugs
V83O1VOZ8L
NIH Clinical Collections (NCC)
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Isoniazid(Tubizid)
TargetMol Bioactive Compound Library
T0972
The Spectrum Collection
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
137.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.31
TPSA
68.01
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
bacterial InhA inhibitor
FABI inhibitor
Target
Enoyl-[acyl-carrier-protein] reductase
CAT
NAPDH
CYP1A2, CYP2C19, CYP2C8, CYP2E1, CYP3A4
antibiotic
Bacterial
Mitophagy
Fatty acid synthase
Pathway
Metabolism
oxidation-reduction
Anti-infection
Autophagy
Indication
tuberculosis
Therapeutic Class
Antitubercular Agents
Source data