General
Preferred name
ISOSORBIDE DINITRATE
Synonyms
Sorbide nitrate ()
Sorbidnitrate ()
Isordil ()
Nitrosorbide ()
ISDN ()
Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide ()
Dilatrate-Sr ()
Cedocard-10 ()
Isomannide-dinitrate ()
Sorbichew ()
Cedocard-5 ()
Sorbid-20 Sa ()
Isosorbide dinitrate, diluted ()
Cedocard-20 ()
Isocard ()
Isoket 10 ()
Isordil Tembids ()
Diluted-isosorbide dinitrate ()
Dilatrate ()
Vascardin ()
Carvasin ()
Diluted isosorbide dinitrate rs ()
Sorbitrate ()
C01DA08 ()
Isosorbidi dinitras dilutes ()
Isoket 5 ()
Sorbid Sa ()
Imtack ()
Isoket 20 ()
Isosorbidi dinitras dilutus ()
Cedocard Ret ()
Isomannide dinitrate ()
Isoket Ret 40 ()
Isosorbide dinitrate, diluted- ()
Diluted isosorbide dinitrate ()
Cedocard-40 ()
Jeridin ()
Soni-Slo ()
Sorbid-40 Sa ()
Cedocard ()
Iso Mack ()
NSC-80038 ()
Angitak ()
Sorbidilat ()
Isoket Ret 20 ()
P&D ID
PD001923
CAS
87-33-2
54650-95-2
Tags
available
prodrug
drug
Approved by
FDA
First approval
1968
1986
Drug Status
investigational
approved
Drug indication
Vasodilator (coronary)
Angina pectoris
Anal fissure
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Isosorbide dinitrate acts as a vasodilator. It is similar to nitroglycerin, but is slower to act. (GtoPdb)
MOA Isosorbide dinitrate is converted to the active nitric oxide to activate guanylate cyclase. This activation increases levels of cyclic guanosine 3',5'-monophosphate (cGMP). cGMP activates protein kinases and causes a series of phosphorylation reactions which leads to dephosphorylation of myosin light chains of smooth muscle fibres. Finally there is a release of calcium ions which causes smooth muscle relaxation and vasodilation.
Cell lines
0
Organisms
1
Compound Sets
23
Cayman Chemical Bioactives
23990
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL6622
ChEMBL Drugs
CHEMBL6622
Drug Repurposing Hub
DrugBank
DB00883
DrugBank Approved Drugs
DB00883
DrugCentral
1505
DrugCentral Approved Drugs
1505
DrugMAP
DMBI4JG
DrugMAP Approved Drugs
DMBI4JG
Enamine BioReference Compounds
Guide to Pharmacology
7051
Mcule NIBR MoA Box Subset
MCULE-2202078269
MedChem Express Bioactive Compound Library
HY-B1409
NCATS Inxight Approved Drugs
IA7306519N
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
isosorbide-dinitrate
TargetMol Bioactive Compound Library
T1479
The Spectrum Collection
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
236.03
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
0
cLogP
-1.06
TPSA
123.2
Fraction CSP3
1.0
Chiral centers
4.0
Largest ring
5.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Guanylate cyclase activator
Natriuretic peptide receptor A agonist
nitric oxide stimulant
Target
Soluble guanylate cyclase
NPR1
GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, NPR1
NO Synthase
Guanylate Cyclase,NOS
Member status
virtual
Indication
angina pectoris, coronary artery disease (CAD)
Therapeutic Class
Vasodilator Agents
Pathway
Immunology/Inflammation
Source data