General
Preferred name
ISOSORBIDE DINITRATE
Synonyms
Isordil ()
Nitrosorbide ()
Sorbide nitrate ()
Sorbidnitrate ()
ISDN ()
Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide ()
Isosorbide dinitrate, diluted ()
Cedocard ()
Cedocard-40 ()
Carvasin ()
Diluted-isosorbide dinitrate ()
Isocard ()
Dilatrate-Sr ()
Dinitrato de isosorbida ()
Isomannide-dinitrate ()
Isomannide dinitrate ()
Cedocard-20 ()
Soni-Slo ()
Sorbichew ()
Diluted isosorbide dinitrate ()
C01DA08 ()
Cedocard Ret ()
Isosorbide dinitrate, diluted- ()
Iso Mack ()
Dinitrate d'isosorbide ()
Angitak ()
Isosorbidi dinitras dilutes ()
Sorbid Sa ()
Diluted isosorbide dinitrate rs ()
Isosorbidi dinitras dilutus ()
Isosorbide dinitrate component of bidil ()
Jeridin ()
Vascardin ()
Isoket Ret 20 ()
Isoket 20 ()
Isoket Ret 40 ()
Imtack ()
Sorbid-20 Sa ()
Sorbid-40 Sa ()
NSC-80038 ()
Dilatrate ()
Isordil Tembids ()
Sorbitrate ()
Cedocard-5 ()
Sorbidilat ()
Isoket 10 ()
Cedocard-10 ()
Isoket 5 ()
P&D ID
PD001923
CAS
87-33-2
54650-95-2
Tags
available
prodrug
drug
Approved by
FDA
First approval
1986
1968
Drug indication
Angina pectoris
Anal fissure
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Isosorbide dinitrate is converted to the active nitric oxide to activate guanylate cyclase. This activation increases levels of cyclic guanosine 3',5'-monophosphate (cGMP). cGMP activates protein kinases and causes a series of phosphorylation reactions which leads to dephosphorylation of myosin light chains of smooth muscle fibres. Finally there is a release of calcium ions which causes smooth muscle relaxation and vasodilation.
DESCRIPTION Isosorbide dinitrate acts as a vasodilator. It is similar to nitroglycerin, but is slower to act. (GtoPdb)
DESCRIPTION Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI)[1].
PRICE 29
DESCRIPTION Isosorbide dinitrate is a vasodilator used to treat angina in coronary artery disease. Isosorbide dinitrate is converted to the active nitric oxide to activate guanylate cyclase. (Enamine Bioactive Compounds)
DESCRIPTION Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
25
Cayman Chemical Bioactives
23990
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL6622
ChEMBL Drugs
CHEMBL6622
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00883
DrugBank Approved Drugs
DB00883
DrugCentral
1505
DrugCentral Approved Drugs
1505
DrugMAP
DMBI4JG
DrugMAP Approved Drugs
DMBI4JG
Enamine Bioactive Compounds
EBC-07863
Enamine BioReference Compounds
Guide to Pharmacology
7051
Mcule NIBR MoA Box Subset
MCULE-2202078269
MedChem Express Bioactive Compound Library
HY-B1409
NCATS Inxight Approved Drugs
IA7306519N
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
isosorbide-dinitrate
TargetMol Bioactive Compound Library
T1479
The Spectrum Collection
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
236.03
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
0
cLogP
-1.06
TPSA
123.2
Fraction CSP3
1.0
Chiral centers
4.0
Largest ring
5.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Guanylate cyclase activator
Natriuretic peptide receptor A agonist
nitric oxide stimulant
Target
Soluble guanylate cyclase
NO Synthase
NPR1
GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, NPR1
Guanylate Cyclase,NOS
Member status
virtual
Indication
angina pectoris, coronary artery disease (CAD)
Pathway
Immunology/Inflammation
Therapeutic Class
Vasodilator Agents
Source data