General
Preferred name
LEVONORDEFRIN
Synonyms
α-methylnoradrenaline ()
corbadrine ()
(-)-Cobefrin ()
(-)-α-Methylnoradrenaline ()
(-)-Nordefrin ()
Nordefrin, l- ()
BA-2818 ()
Nordefrin ()
Neo-cobefrin ()
L-nordefrin ()
L-.alpha.-methylnoradrenaline ()
NSC-757084 ()
L-norephedrine, 3,4-dihydroxy- ()
Nordefrin (-)-form ()
BA 2818 ()
P&D ID
PD001917
CAS
829-74-3
18829-78-2
Tags
natural product
drug
available
Approved by
FDA
First approval
1960
Drug Status
approved
Drug indication
Discovery agent
Adrenergic (vasoconstrictor)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION α-methylnoradrenaline (corbadrine) is a catecholamine sympathomimetic drug. (GtoPdb)
Compound Sets
16
Cayman Chemical Bioactives
23993
ChEMBL Approved Drugs
CHEMBL677
ChEMBL Drugs
CHEMBL677
Drug Repurposing Hub
DrugBank
DB06707
DrugBank Approved Drugs
DB06707
DrugCentral
4482
DrugCentral Approved Drugs
4482
DrugMAP
DMWDJ0H
Guide to Pharmacology
508
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL677
MedChem Express Bioactive Compound Library
HY-107915
NCATS Inxight Approved Drugs
V008L6478D
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
183.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
0.48
TPSA
86.71
Fraction CSP3
0.33
Chiral centers
2.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, SLC6A2
Adrenergic Receptor
Indication
hemorrhage
MOA
Vasodilator
Pathway
GPCR/G protein
Neuronal Signaling
Source data