General
Preferred name
MAPROTILINE HYDROCHLORIDE
Synonyms
CPD000148117 ()
Maprotiline HCl ()
Ludiomil ()
Psymion ()
Deprilept ()
Maprotiline (hydrochloride) ()
BA-34276 ()
NSC-757085 ()
BA-34,276 ()
Maprotiline (hydrochloride) (CRM) ()
P&D ID
PD001914
CAS
10347-81-6
10262-69-8
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antidepressant
First approval
1980
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective norepinephrine reuptake inhibitor (LOPAC library)
DESCRIPTION Noradrenalin re-uptake inhibitor (Tocriscreen Total)
Cell lines
0
Organisms
2
Compound Sets
15
AdooQ Bioactive Compound Library
A10555
Bioprocess diversity set
Cayman Chemical Bioactives
33077
32702
15892
ChEMBL Approved Drugs
CHEMBL1237135
ChEMBL Drugs
CHEMBL1237135
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101781
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0444
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Maprotiline-hydrochloride
TargetMol Bioactive Compound Library
T0172
The Spectrum Collection
Tocriscreen Total
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
313.16
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
4.63
TPSA
12.03
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Reuptake
Biological process
Mitosis & chromosome segregation
Pathway
GPCR/G protein
Neuroscience
Immunology/Inflammation
Autophagy
Target
5-HT
mAChR
Adrenergic Receptor
H1 receptor
Noradrenaline transporter (Sodium-dependent)
Source data