General
Preferred name
MECHLORETHAMINE
Synonyms
Chlormethine ()
Chlormethine hydrochloride ()
Mechlorethamine HCl ()
MECHLORETHAMINE HYDROCHLORIDE ()
Mustargen hydrochloride ()
HN2 ()
Nitrogen mustard hydrochloride ()
Dichloromethyldiethylamine hydrochloride ()
Bis(2-chloroethyl)methylamine hydrochloride ()
HN2 hydrochloride ()
Methyldi(2-chloroethyl)amine hydrochloride ()
Di(2-chloroethyl)methylamine hydrochloride ()
Methylbis(2-chloroethyl)amine hydrochloride ()
Chlormethine (hydrochloride) ()
NSC-10107 ()
Chlorethazine ()
NSC-128663 ()
NSC-757087 ()
Mustargen ()
Nitrogen mustard (hn 2) ()
Mustine ()
Valchlor ()
Chlormethini hydrochloridum ()
Chlormethine hcl ()
NSC-762 ()
Nitrogen mustard n-oxide hydrochloride ()
Nitrogen Mustard ()
P&D ID
PD001913
CAS
55-86-7
51-75-2
159923-90-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1949
Drug Status
investigational
approved
Drug indication
Antineoplastic
Hodgkin lymphoma
T-cell lymphoma
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Mechlorethamine is a nitrogen mustard and is the prototype alkylating anticancer chemotherapeutic. In addition, mechlorethamine is used in the synthesis of the opioid analgesic .
(GtoPdb)
PHARMACODYNAMICS
Mechlorethamine also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy. The drug is an analogue of mustard gas and was derived from toxic gas warfare research. Mechlorethamine is a nitrogen mustard alkylating agent. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
DESCRIPTION
Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
7
Organisms
0
Compound Sets
18
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Approved Oncology Drugs
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
60
Molecular Weight
155.03
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
1.4
TPSA
3.24
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
DNA Damage/DNA Repair
Target
DNA/RNA Synthesis
Therapeutic Class
Anticancer Agents
Source data
