General
Preferred name
FENBENDAZOLE
Synonyms
Fenbendazol ()
Phenbendasol ()
Panacur ()
Fenbendazol,Phenbendasol ()
Fenbendazole for veterinary use ()
HOE-881Y ()
HOE-881V ()
HOE 881V ()
NSC-757824 ()
HOE 881Y ()
Panacur aquasol ()
Fenbendazole-d3 ()
P&D ID
PD001910
CAS
43210-67-9
1228182-47-5
Tags
available
drug
Approved by
FDA
Drug Status
approved
investigational
vet_approved
Max Phase
2.0
Drug indication
Helminthiasis
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1¦Á. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1].
PRICE 29
DESCRIPTION Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites with an IC50 of about 0.01 μg/ml (BOC Sciences Bioactive Compounds)
DESCRIPTION Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
3
Compound Sets
18
BOC Sciences Bioactive Compounds
fenbendazole-cas-43210-67-9-334246
Cayman Chemical Bioactives
19687
27842
ChEMBL Drugs
CHEMBL37161
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB11410
DrugBank Approved Drugs
DB11410
DrugCentral
4536
DrugCentral Approved Drugs
4536
Ki Database
Fenbendazole
MedChem Express Bioactive Compound Library
HY-B0413
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Fenbendazole(Panacur)
TargetMol Bioactive Compound Library
T1141
The Spectrum Collection
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
299.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
3.89
TPSA
67.01
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Indication
gastrointestinal parasites, gastrointestinal roundworms
Target
TUBB
antibiotic
HIF/HIF Prolyl-Hydroxylase
Microtubule/Tubulin
Parasite
Antiparasitic
HIF
MOA
tubulin polymerization inhibitor
Pathway
Chromatin/Epigenetic
Metabolism
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
cytoskeleton
Metabolic Enzyme/Protease
Source data