General
Preferred name
FERULIC ACID
Synonyms
(E)-Ferulic acid ()
Fumalic acid (Ferulic acid) ()
Fumalic Acid ()
3-(4-hydroxy-3-methoxyphenyl)acrylic acid ()
Sodium ferulic ()
Coniferic acid ()
(E)-Coniferic acid ()
FERULATE ()
trans-Ferulic acid ()
P&D ID
PD001909
CAS
1135-24-6
97274-61-8
537-98-4
Tags
available
covalent binder
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 ¦ÌM for FGFR1 and FGFR2, respectively.
DESCRIPTION
(E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of ¦Â-catenin (¦Â-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.
PRICE
29
DESCRIPTION
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of ??-catenin, resulting in proteasomal degradation of ??-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin.t(E)-Ferulic acid exert both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
DESCRIPTION
Ferulic acid is an aromatic compound, abundant in plant cell walls. trans-Ferulic acid can be used as an antioxidant and food preservative. It also has binding affinity towards amyloid-beta precursor protein, Ki=0.77 nM.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
5
Organisms
2
Compound Sets
14
Cayman Chemical Bioactives
ChEMBL Drugs
CovalentInDB
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
56
Molecular Weight
194.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
1.5
TPSA
66.76
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
¦Â-catenin
CA1, CA12, CA14, CA2, CA4, CA6, CA9
Endogenous Metabolite
FGFR
Bcl-2 Family
Ferroptosis
β-catenin
MOA
Antioxidant
Pathway
Metabolic Enzyme/Protease
Protein Tyrosine Kinase/RTK
Apoptosis
Stem Cell/Wnt
Source data
