General
Preferred name
MEFENAMIC ACID
Synonyms
CN-35355 ()
CI 473 ()
CI 473, CN-35355 ()
Mefenaminic acid ()
Acido mefenamico ()
Mendys ()
M01AG01 ()
Meflam 500 ()
Contraflam ()
NSC-94437 ()
Ponstan Fte ()
Mephenaminic acid ()
Mephenamic acid ()
Ponstel ()
Dysman-250 ()
INF-3355 ()
Opustan 500 ()
Ponstan ()
Meflam 250 ()
Gardan ()
J2.344B ()
Dysman-500 ()
Opustan 250 ()
CI-473 ()
Acide mefenamique ()
Mefenamate ()
Mefenamic Acid-d4 ()
P&D ID
PD001903
CAS
61-68-7
1216745-79-7
Tags
available
drug
Approved by
FDA
First approval
1967
Drug indication
rheumatic disease
Dysmenorrhea
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Mefenamic acid is an anthranilic acid derivative (or fenamate) class NSAID drug. (GtoPdb)
DESCRIPTION Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 ¦ÌM for hCOX-1 and hCOX-2, respectively.
PRICE 29
DESCRIPTION Mefenamic acid is a non-steroidal anti-inflammatory drug and a prostaglandin G/H synthase 2 (COX-2) inhibitor. It is used for the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever. (Enamine Bioactive Compounds)
DESCRIPTION Mefenamic acid (CN-35355) is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
2
Compound Sets
27
Cayman Chemical Bioactives
23650
31788
ChEMBL Approved Drugs
CHEMBL686
ChEMBL Drugs
CHEMBL686
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00784
DrugBank Approved Drugs
DB00784
DrugCentral
1663
DrugCentral Approved Drugs
1663
DrugMAP
DMK7HFI
DrugMAP Approved Drugs
DMK7HFI
DrugMatrix
Enamine Bioactive Compounds
EBC-03713
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101371
Guide to Pharmacology
2593
Ki Database
Mefenamic acid
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL686
MedChem Express Bioactive Compound Library
HY-B0574
NCATS Inxight Approved Drugs
367589PJ2C
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
mefenamic-acid
TargetMol Bioactive Compound Library
T0890
The Spectrum Collection
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
241.11
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
3.75
TPSA
49.33
Fraction CSP3
0.13
Chiral centers
0.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX
COX-1
COX-2
KCNQ1, PTGS1, PTGS2, TRPM3
Indication
primary dysmenorrhea (PD)
MOA
cyclooxygenase inhibitor
Therapeutic Class
Antiinflammatory Agents
Pathway
Immunology/Inflammation
Neuroscience
Source data