General
Preferred name
PICROTOXININ
Synonyms
P&D ID
PD001901
CAS
17617-45-7
Tags
available
natural product
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits ¦Á1¦Â2¦Ã2L GABAA receptor with an IC50 of 1.15 ¦ÌM[1].
PRICE 33
DESCRIPTION Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 ??M for ??1??2??2L GABAA. Picrotoxinin shows convulsant properties.
DESCRIPTION Picrotoxinin is a plant-derived neurotoxic sesquiterpenoid compound. (GtoPdb)
DESCRIPTION Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties. (TargetMol Bioactive Compound Library)
Compound Sets
10
Concise Guide to Pharmacology 2017/18
2291
Concise Guide to Pharmacology 2019/20
2291
Concise Guide to Pharmacology 2021/22
2291
Concise Guide to Pharmacology 2023/24
2291
CZ-OPENSCREEN Bioactive Library
Guide to Pharmacology
2291
ReFrame library
TargetMol Bioactive Compound Library
T16535
The Spectrum Collection
ZINC Tool Compounds
ZINC000004098166
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
292.09
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
0
cLogP
-0.06
TPSA
85.36
Fraction CSP3
0.73
Chiral centers
8.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Chloride channel
GABAA
GABA Receptor
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Source data