General
Preferred name
MEBHYDROLIN
Synonyms
Incidal ()
Diazolin ()
Mebhydroline 1,5-naphthalenedisulfonate salt ()
Omeril ()
Diazoline ()
Mebhydroline 1,5-naphtalenedisulfonate ()
Mebhydroline ()
Mebhydrolin (napadisylate) ()
Diazoline, Diazolin, Incidal, Omeril ()
Mebhydrolin napadisylate ()
5-benzyl-2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole ()
Mebhydrolin napadisilate ()
NSC-757830 ()
Fabahistin ()
Bexidal ()
Mebhidrolina ()
Mebhydroline (1,5-naphthalenedisulfonate) ()
P&D ID
PD001894
CAS
524-81-2
6153-33-9
Tags
available
drug
First approval
1954
Drug Status
approved
experimental
investigational
Max Phase
2.0
Drug indication
allergic disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Mebhydrolin is a specific histamine H1 receptor antagonist.
PRICE 29
DESCRIPTION Mebhydrolin (Mebhydroline) is a specific histamine H1 receptor antagonist.
PRICE 29
DESCRIPTION Mebhydrolin is a histamine H1 receptor antagonist. (Enamine Bioactive Compounds)
DESCRIPTION PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active (TargetMol Bioactive Compound Library)
DESCRIPTION Mebhydrolin napadisylate (Incidal) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis. (TargetMol Bioactive Compound Library)
Compound Sets
17
Cayman Chemical Bioactives
40281
ChEMBL Drugs
CHEMBL1625607
Drug Repurposing Hub
DrugBank
DB13808
DrugCentral
1643
DrugCentral Approved Drugs
1643
DrugMatrix
Enamine Bioactive Compounds
EBC-03753
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-B1303A
HY-B1303
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
mebhydrolin-napadisylate
TargetMol Bioactive Compound Library
H025-0135C
T0113
The Spectrum Collection
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
276.16
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
3
cLogP
3.68
TPSA
8.17
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
MOA
5-HT Receptor
AChR antagonist
antihistamine
Indication
allergic rhinitis, urticaria
Target
Histamine Receptor
ADC Cytotoxin,Histamine Receptor
HT
mAChR
Source data