General
Preferred name
PROGLUMIDE
Synonyms
Proglumide sodium salt ()
Proglumide (sodium) ()
Proglumida ()
Binoside ()
CR-242 ()
Promid ()
NSC-757841 ()
Milid ()
W-5219 ()
Xylamide ()
Dl-proglumide ()
Nulsa ()
Xyde ()
Ulcutin ()
Gastrotopic ()
Midelid ()
P&D ID
PD001891
CAS
6620-60-6
99247-33-3
24485-90-3
Tags
available
drug
Drug indication
Peptic ulcer
Influenza virus infection
Drug Status
withdrawn
approved
experimental
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK¡¯s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities[1][2][3][4][5].
PRICE 29
DESCRIPTION Selective cholecystokinin receptor antagonist (LOPAC library)
DESCRIPTION Proglumide (Binoside) is a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers. (TargetMol Bioactive Compound Library)
DESCRIPTION Subtype-selective kappa agonist (Tocris Bioactive Compound Library)
DESCRIPTION Proglumide sodium salt is a non-selective cholecystokinin (CCK) antagonist. Proglumide sodium salt is a non-peptide cholecystokinin receptor antagonist that has greater selectivity for the CCKA subtype. (BOC Sciences Bioactive Compounds)
Compound Sets
23
AdooQ Bioactive Compound Library
A18171
BOC Sciences Bioactive Compounds
proglumide-sodium-salt-cas-99247-33-3-item-77676
ChEMBL Approved Drugs
CHEMBL316561
ChEMBL Drugs
CHEMBL316561
CZ-OPENSCREEN Bioactive Library
DrugBank
DB13431
DrugCentral
2281
DrugCentral Approved Drugs
2281
DrugMAP
DM4MF9V
DrugMatrix
Guide to Pharmacology
893
Ki Database
Proglumide
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-2438450007
MedChem Express Bioactive Compound Library
HY-B1330
HY-103354
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T1052
The Spectrum Collection
Tocris Bioactive Compound Library
1478
Withdrawn 2.0
w29
External IDs
39
Properties
(calculated by RDKit )
Molecular Weight
334.19
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
10
Ring Count
1
Aromatic Ring Count
1
cLogP
2.3
TPSA
86.71
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CCK
Cholecystokinin
Cholecystokinin Receptor
Primary Target
Non-selective CCK
MOA
Antagonist
CCK2 (CCKB/Gastrin) Antagonists
Member status
member
ATC
A02BX06
Toxicity type
respiratory
Pathway
GPCR/G protein
Neuronal Signaling
Source data