General
Preferred name
TRAMIPROSATE
Synonyms
3-Amino-1-propanesulfonic acid sodium ()
3-AMINO-1-PROPANESULFONIC ACID ()
Homotaurine ()
Alzhemed ()
Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid ()
NC-531 ()
Tramiprosato ()
NSC-77071 ()
NC-758 ()
3-aminopropane sulfonic acid ()
Acamprosate related compound a ()
P&D ID
PD001887
CAS
3687-18-1
14650-46-5
Tags
available
drug candidate
Drug indication
Alzheimer disease
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble A?? and maintains it in a non-protofibrillar form.It is a GABA analog with neuroprotective, anticonvulsant, and antihypertensive activity.
DESCRIPTION
Tramiprosate, also nemed homotaurine, is an orally-administered, sulfated glycosaminoglycan mimic that targets amyloid β. γ-secretase: IC50 = 12 nM; Aβ40: IC50 = 7.4 nM; Aβ42: IC50 = 7.9 nM; gamma-secretase express: EC5050 = 7 nM (CHO cells ); displacement of [3H]L685458 from human SPP express: IC50 = 28.7 µM (HEK293 cells).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Homotaurine is an orally active and brain-penetrant natural amino acid. It binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Homotaurine is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects. It is investigated for treatment strokes and alzheimer's disease.
(Enamine Bioactive Compounds)
DESCRIPTION
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GABA analog with neuroprotective, anticonvulsant, and antihypertensive activity.
(TargetMol Bioactive Compound Library)
DESCRIPTION
GABA-A receptor agonist
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
16
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
51
Molecular Weight
139.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.78
TPSA
80.39
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
GABA-A
Target
Amyloid-¦Â
Amyloid-β
Aβ
GABA
Amyloid-??
APP
GABA Receptor
Member status
member
MOA
beta-Amyloid (Abeta) Aggregation Inhibitors
Antiamyloidogenic Agents
beta amyloid protein neurotoxicity inhibitor
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Solubility
Soluble in DMSO
Source data
