General
Preferred name
MELPHALAN
Synonyms
SARCOLYSIN ()
MELPHALAN HYDROCHLORIDE ()
MelphalanAlkeranPhenylalanine mustard hydrochlorideMelphalan hydrochlorideL-PAMAlanine Nitrogen MustardL-Phenylalanine Mustard hydrochlorideL-Sarcolysine hydrochlorideL-Alanine, 3-(p-[bis(2-chloroethyl)amino]phenyl)-, hydrochlorideCB 3025 ()
Alanine Nitrogen Mustard ()
Phenylalanine Mustard ()
NSC-8806 ()
NCI-C04853 ()
NSC-241286 ()
Sarcolycin, l- ()
L-Sarcolysin ()
L-phenylalanine mustard ()
Melfalan ()
CB 3025 ()
Alkeran ()
SK 15673 ()
SK-15673 ()
CB-3025 ()
L-PAM ()
CB 3025 HYDROCHLORIDE ()
Melphalan hcl ()
CB-3025 HYDROCHLORIDE ()
Evomela ()
Ivra ()
Hepzato ()
Alkeran hydrochloride ()
Phelinun ()
Sarcolysin hydrochloride, l- ()
P&D ID
PD001871
CAS
148-82-3
3223-07-2
Tags
available
drug
nuisance
Approved by
FDA
First approval
1964
1992
Drug indication
Multiple myeloma
Intrahepatic cholangiocarcinoma
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations may contain melphalan hydrochloride. (GtoPdb)
DESCRIPTION Binds mot-2; selectively cytotoxic in cancer cells (Tocris Bioactive Compound Library)
DESCRIPTION Melphalan is a phenylalanine derivative of nitrogen mustard and is a bifunctional alkylating agent which is useful against selected human neoplastic diseases. (BOC Sciences Bioactive Compounds)
Cell lines
69
Organisms
2
Compound Sets
19
BOC Sciences Bioactive Compounds
melphalan-hydrochloride-cas-3223-07-2-item-84-465315
Cayman Chemical Bioactives
16665
ChEMBL Approved Drugs
CHEMBL852
CHEMBL1200863
ChEMBL Drugs
CHEMBL852
CHEMBL1200863
Drug Repurposing Hub
DrugBank
DB01042
DrugBank Approved Drugs
DB01042
DrugCentral
1678
DrugCentral Approved Drugs
1678
DrugMAP
DMOLNHF
DrugMAP Approved Drugs
DMOLNHF
Guide to Pharmacology
7620
NCATS Inxight Approved Drugs
Q41OR9510P
NIH Approved Oncology Drugs
301128
NPC Screening Collection
Nuisance compounds in cellular assays
ReFrame library
The Spectrum Collection
Tocris Bioactive Compound Library
4619
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
304.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
1
Aromatic Ring Count
1
cLogP
1.93
TPSA
66.56
Fraction CSP3
0.46
Chiral centers
1.0
Largest ring
6.0
QED
0.72
Structural alerts
1
Genotoxic
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Other Apoptosis
MOA
DNA Alkylating
DNA alkylating agent, DNA inhibitor
Pathway
DNA Damage/DNA Repair
Target
DNA
Indication
multiple myeloma
Therapeutic Class
Anticancer Agents
Solubility
Soluble in Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
Source data