General
Preferred name
METHACHOLINE CHLORIDE
Synonyms
Acetyl-beta-methylcholine chloride ()
Acetyl-¦Â-methylcholine chloride ()
METHACHOLINE ()
Mecholyl chloride ()
Acetyl-β-methylcholine chloride ()
Mecholyl chloride, Acetyl-β-methylcholine chloride ()
Acetyl-??methylcholine chloride ()
Mecholyl chloride, Acetyl-??methylcholine chloride ()
Methacholine (chloride) ()
Mecholyl chloride, Acetyl-¦Â-methylcholine chloride ()
Acetyl-?-methylcholine (chloride) ()
Provocholine ()
Cloruro de metacolina ()
NSC-757090 ()
Chlorure de methacholine ()
P&D ID
PD001866
CAS
62-51-1
55-92-5
2410-07-3
Tags
available
drug
Drug indication
bronchial hyperreactivity
Asthma
Drug Status
approved
Max Phase
4.0
First approval
1986
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Methacholine (Acetyl-¦Â-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].
PRICE 29
DESCRIPTION Methacholine Chloride (Acetyl-??-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma.
DESCRIPTION M1 muscarinic acetylcholine receptor agonist (LOPAC library)
DESCRIPTION Methacholine Chloride (Acetyl-β-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (TargetMol Bioactive Compound Library)
Compound Sets
13
Cayman Chemical Bioactives
23092
ChEMBL Approved Drugs
CHEMBL1200764
ChEMBL Drugs
CHEMBL1200764
DrugMAP
DMGS4QH
DrugMAP Approved Drugs
DMGS4QH
DrugMatrix
Ki Database
Methacholine
LOPAC library
MedChem Express Bioactive Compound Library
HY-A0083
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
methacholine-chloride
TargetMol Bioactive Compound Library
T1682
The Spectrum Collection
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
195.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-2.35
TPSA
26.3
Fraction CSP3
0.88
Chiral centers
1.0
Largest ring
0.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
M1
Target
mAChR
AChR
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data