General
Preferred name
METHENAMINE
Synonyms
Methenamine sulfate ()
Mandelamine ()
Methenamine (hippurate) ()
Hexamine (hippurate) ()
METHENAMINE HIPPURATE ()
METHENAMINE MANDELATE ()
CALCIUM HEXAMINE THIOCYANATE ()
Hexamine ()
INS NO.239 ()
NSC-26346 ()
Metenamina ()
Urotropin ()
E-239 ()
Uritone ()
INS-239 ()
Hexamethylene tetramine ()
NSC-403347 ()
E239 ()
Aminoform ()
Hexamine Hippurate ()
Hiprex ()
Urex ()
Hexamine mandelate ()
P&D ID
PD001865
CAS
100-97-0
24911-88-4
5714-73-8
19442-87-6
587-23-5
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1967
Drug Status
vet_approved
approved
Max Phase
4.0
Drug indication
Nasal congestion
osteomyelitis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Methenamine is a heterocyclic organic compound. It is metabolised to formaldehyde, which acts as a nonspecific bactericidal agent. Methenamine is administered as the hippuric acid salt, methenamine hippurate (PubChem CID 21945).
(GtoPdb)
DESCRIPTION
Methenamine hippurate (Hexamine hippurate) is an orally active urinary antiseptic agent with a wide antibacterial spectrum. Methenamine hippurate is effective against most common urinary tract pathogens[1][2].
PRICE
29
DESCRIPTION
Methenamine is a urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy. Methenamine does not have antibacterial properties in an alkaline environment (pH?6); however, in a more acidic environment (pH<6), methenamine is hydrolyzed to formaldehyde. Formaldehyde is considered to be highly bactericidal.
(Enamine Bioactive Compounds)
DESCRIPTION
Methenamine Hippurate is a component of Hiprex, with antibacterial activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
82
Molecular Weight
140.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
0
cLogP
-1.02
TPSA
12.96
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bacterial
antibiotic
Pathway
Microbiology&virology
Microbiology/virology
Anti-infection
Indication
urinary tract infections
MOA
bacterial DNA inhibitor
Source data
