General
Preferred name
METHENAMINE
Synonyms
Methenamine sulfate ()
METHENAMINE HIPPURATE ()
Mandelamine ()
Methenamine (hippurate) ()
CALCIUM HEXAMINE THIOCYANATE ()
METHENAMINE MANDELATE ()
Hexamine (hippurate) ()
NSC-403347 ()
Urotropin ()
INS NO.239 ()
INS-239 ()
NSC-26346 ()
Aminoform ()
Hexamine ()
E239 ()
Hexamethylenamine ()
Uritone ()
Hexamethylene tetramine ()
Hexamethylenetetramine ()
E-239 ()
Hexamine Hippurate ()
Hiprex ()
Urex ()
Hexamine mandelate ()
Hexydaline ()
Hexamethylenamine mandelate ()
P&D ID
PD001865
CAS
100-97-0
5714-73-8
24911-88-4
19442-87-6
587-23-5
Tags
prodrug
drug candidate
natural product
drug
available
Approved by
FDA
First approval
1967
Drug Status
approved
vet_approved
Max Phase
Phase 4
Drug indication
Antibacterial (urinary)
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Methenamine is a heterocyclic organic compound. It is metabolised to formaldehyde, which acts as a nonspecific bactericidal agent. Methenamine is administered as the hippuric acid salt, methenamine hippurate (PubChem CID 21945). (GtoPdb)
Compound Sets
19
Cayman Chemical Bioactives
24004
ChEMBL Approved Drugs
CHEMBL1201270
CHEMBL1201104
CHEMBL3833312
ChEMBL Drugs
CHEMBL1201270
CHEMBL3707448
CHEMBL1201104
CHEMBL3833312
Drug Repurposing Hub
DrugBank
DB06799
DrugBank Approved Drugs
DB06799
DrugCentral
3344
DrugCentral Approved Drugs
3344
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
10913
MedChem Express Bioactive Compound Library
HY-B1691
NCATS Inxight Approved Drugs
J50OIX95QV
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
methenamine-hippurate
TargetMol Bioactive Compound Library
T8365
The Spectrum Collection
External IDs
78
Properties
(calculated by RDKit )
Molecular Weight
140.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
0
cLogP
-1.02
TPSA
12.96
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
Bacterial
antibiotic
Indication
urinary tract infections
MOA
bacterial DNA inhibitor
Source data