General
Preferred name
METHOXAMINE HYDROCHLORIDE
Synonyms
Methoxamine HCl ()
Vasoxine HCl ()
Vasoxine ()
Vasoxyl ()
NSC-757102 ()
P&D ID
PD001861
CAS
61-16-5
390-28-3
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
alpha1 Adrenoceptor agonist
(LOPAC library)
DESCRIPTION
Methoxamine Hydrochloride is an alpha-1 adrenergic agonist, similar in structure to butaxamine and 2,5-DMA. It causes prolonged peripheral vasoconstriction. It induces vasoconstriction of skin and splanchnic blood vessels, thus increasing peripheral vascular resistance and raising mean arterial blood pressure. lt is used for the treatment of paroxysmal supraventricular tachycardia and is used as a booster in the state of low blood pressure. It has been listed.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
9
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Enamine BioReference Compounds
LOPAC library
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
14
Molecular Weight
247.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
1.51
TPSA
64.71
Fraction CSP3
0.45
Chiral centers
2.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha1
Pathway
Neuroscience
GPCR/G protein
Target
Adrenergic Receptor
MOA
Adrenergic Receptor antagonist
Solubility
Soluble in DMSO, not in water
Source data
