General
Preferred name
METHOXSALEN
Synonyms
7H-furo(3,2-g)(1)benzopyran-7-one, 9-methoxy- ()
Methoxy-8-psoralen ()
Methoxsalen298-81-7 ()
8-Methoxypsoralen ()
Xanthotoxin ()
8-MOP ()
Xanthotoxin, NCI-C55903 ()
Methoxsalen8-MOPMethoxa-Dome8-MethoxypsoralenOxsoralen8-Methoxy-2',3',6,7-furocoumarin8-MethoxypsoralenePuvalenAmmodinOxoralen ()
Puvalen ()
Uvadex ()
Deltasoralen ()
NSC-45923 ()
METHOXSALEN COMPONENT OF SM-88 ()
Oxsoralen-Ultra ()
Puvasoralen-8 ()
Vitpso ()
Oxsoralen ()
Meladinine ()
Metoxalen ()
Oxypsoralen ()
8-methoxsalen ()
P&D ID
PD001860
CAS
298-81-7
12692-94-3
Tags
available
probe
drug
natural product
Approved by
FDA
First approval
1954
Drug indication
Psoriasis vulgaris
Cutaneous T-cell lymphoma
Lymphoma
Drug Status
approved
Max Phase
4.0
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Methoxsalen (xanthotoxin) is a naturally occurring furocoumarin compound that is present in several species of plants, including Psoralea corylifolia (babchi) which is a traditional medicinal plant and Ammi majus (bishop's flower).
(GtoPdb)
DESCRIPTION
Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.
PRICE
29
DESCRIPTION
Methoxsalen (NCI-C55903) is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity.
DESCRIPTION
Methoxsalen is a naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is used for the treatment of psoriasis and vitiligo.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
9
Organisms
0
Compound Sets
30
Axon Medchem Screening Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
High-quality chemical probes
JUMP-Target 1 Compound Set
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Approved Oncology Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
55
Molecular Weight
216.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.55
TPSA
52.58
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
DNA-Damaging Drugs
Cytochrome P450 CYP1A2 Inhibitors
DNA synthesis inhibitor
Target
CYP1A1, CYP1A2, CYP2A13, CYP2A6, CYP3A4
CYP2A6 inhibitor
CYP1A2
Cytochrome P450
P450 (e.g. CYP17)
Indication
psoriasis
Therapeutic Class
Anticancer Agents
Pathway
Metabolic Enzyme/Protease
Source data
