General
Preferred name
METHYLDOPA
Synonyms
L-alpha-Methyl DOPA ()
L-(-)- α-Methyldopa ()
L-(-)-¦Á-Methyldopa (hydrate) ()
L-(-)-¦Á-Methyldopa (hydrochloride) ()
MK-351 hydrate ()
Methyldopa hydrate ()
Methyldopa hydrochloride ()
Methyldopa Sesquihydrate ()
L-(-)-??-Methyldopa hydrate ()
MK-351 ()
Alpha-Methyldopa Sesquihydrate ()
L-(-)-??-Methyldopa ()
L-(-)-??-Methyldopa (hydrate) ()
L-(-)-??-Methyldopa (hydrochloride) ()
Methyldopa (L,-) ()
METHYLDOPA ANHYDROUS ()
Methyldopa (hydrate) ()
L-(-)-α-Methyldopa (hydrate) ()
MK-351 (hydrate) ()
L-(-)-¦Á-Methyldopa hydrate ()
Methyldopa hydrate, MK-351 hydrate ()
MK-351 hydrochloride ()
L-α-Methyl DOPA Hydrate ()
L-α-methyldopa ()
Methyldopa (levorotatory) ()
Metalpha 500 ()
(s)-(-)-.alpha.-methyldopa ()
Dopamet ()
L-.alpha.-methyldopa ()
Medomet ()
NSC-760080 ()
BAYER-1440L ()
Anhydrous methyldopa ()
Methyldopa, anhydrous ()
Aldomet ()
Alpha-Methyldopa ()
NSC-169916 ()
(-)-.alpha.-methyldopa ()
.alpha.-methyl-l-dopa ()
J9.247I ()
Lederdopa ()
Metalpha 250 ()
L-(?)-?-Methyldopa ()
P&D ID
PD001858
CAS
41372-08-1
555-30-6
133161-54-3
884-39-9
Tags
natural product
drug
available
Approved by
FDA
First approval
1962
Drug Status
approved
Drug indication
Hypertension
Antihypertensive
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION L-α-methyldopa is metabolised to α-methylnorepinephrine in the brain, the metabolite being a selective agonist of α2 adrenoceptors. Clinical L-α-methyldopa use has largely been replaced by safer alternatives. (GtoPdb)
DESCRIPTION L-aromatic amino acid decarboxylase inhibitor; antihypertensive (LOPAC library)
DESCRIPTION Aromatic L-amino acid decarboxylase inhibitor (Tocriscreen Total)
DESCRIPTION Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg. (BOC Sciences Bioactive Compounds)
DESCRIPTION MK-351 hydrochloride is an alpha-adrenergic agonist selective for α2-adrenergic receptors. It is a psychoactive drug used as a sympatholytic or antihypertensive. It plays a role in treating hypertension and gestational hypertension. It has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, which converts L-DOPA into dopamine. It is converted to α-methylnorepinephrine by dopamine beta-hydroxylase. (BOC Sciences Bioactive Compounds)
DESCRIPTION L-α-Methyl DOPA Hydrate is an alpha-adrenergic agonist used as a sympatholytic or antihypertensive. (BOC Sciences Bioactive Compounds)
Compound Sets
31
BOC Sciences Bioactive Compounds
methyldopa-cas-555-30-6-item-84-334744
mk-351-hydrochloride-cas-884-39-9-item-474887
l-methyl-dopa-hydrate-cas-41372-08-1-item-92067
Cayman Chemical Bioactives
21814
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL459
ChEMBL Drugs
CHEMBL459
Concise Guide to Pharmacology 2017/18
5217
Concise Guide to Pharmacology 2019/20
5217
Concise Guide to Pharmacology 2021/22
5217
Concise Guide to Pharmacology 2023/24
5217
Drug Repurposing Hub
DrugBank
DB00968
DrugBank Approved Drugs
DB00968
DrugCentral
1762
DrugCentral Approved Drugs
1762
DrugMAP
DM5I621
DrugMAP Approved Drugs
DM5I621
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101953
Guide to Pharmacology
5217
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL459
MedChem Express Bioactive Compound Library
HY-B0225B
NCATS Inxight Approved Drugs
M4R0H12F6M
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Methyldopa(Aldomet)
l-a-methyldopa-hydrate
TargetMol Bioactive Compound Library
T0505
T5954
The Spectrum Collection
Tocriscreen Total
ZINC Tool Compounds
ZINC000000020255
External IDs
69
Properties
(calculated by RDKit )
Molecular Weight
211.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
0.44
TPSA
103.78
Fraction CSP3
0.3
Chiral centers
1.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Aromatic amino acid decarboxylase
Target
Adrenergic Receptor
Adrenergic receptor alpha-2
Dopa decarboxylase
ADRA2A, ADRA2B, ADRA2C, DDC
Endogenous Metabolite
5-HT Receptor,Adrenergic Receptor,Decarboxylase,Dopamine Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Metabolic Enzyme/Protease
MOA
Dopa decarboxylase inhibitor
Adrenergic Receptor agonist
Indication
hypertension
Therapeutic Class
Antihypertensive Agents
Solubility
10 mM in DMSO
Soluble in DMSO
Source data