General
Preferred name
NIACIN
Synonyms
nicotinic acid ()
Nicotinic acid-(ring-d4) ()
Nicotinic acid-d4 ()
Vitamin B3 ()
Nicotinic Acid59-67-6 ()
Vitamin B3-d4 ()
Wampocap ()
Niaspan Titration Starter Pack ()
Niaspan ()
Niacin component of advicor ()
Acido nicotinico ()
NSC-169454 ()
Niacin extended release ()
Niacin Td ()
Niacor ()
Nicotinate ()
Nicotinic Acid ()
Nicangin ()
Acidum nicotinicum ()
Acide nicotinique ()
Niacin component of simcor ()
Nicolar ()
Niaspan Er ()
P&D ID
PD001840
CAS
59-67-6
123574-58-3
101113-41-1
66148-15-0
Tags
available
drug
Approved by
FDA
First approval
1957
1982
Drug indication
HIV infection
Lipid metabolism disorder
Drug Status
approved
investigational
nutraceutical
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Nicotinic acid (niacin) is a form of vitamin B3 and it is the precursor for NAD and NADP.
(GtoPdb)
DESCRIPTION
Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases[1][2].
PRICE
29
DESCRIPTION
Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions. Niacin inhibits hepatocyte diacylglycerol acyltransferase-2, and a high density lipoprotein (HDL) catabolism receptor.
(Enamine Bioactive Compounds)
DESCRIPTION
Niacin (Nicotinic acid) is a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is the deuterium substitute for Niacin and is used to track Niacin metabolism in the body.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
31
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
76
Molecular Weight
123.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
0.78
TPSA
50.19
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Metabolism
Metabolic Enzyme/Protease
Member status
member
MOA
nicotinic receptor agonist
NAD precursor, vitamin B
Target
DGAT2, HCAR1, HCAR2, HCAR3, NNMT, QPRT
Endogenous Metabolite
Vitamin
VB3
Indication
hypertriglyceridemia
Source data
