General
Preferred name
NIACIN
Synonyms
nicotinic acid ()
Vitamin B3 ()
Nicotinic Acid59-67-6 ()
Nicolar ()
Wampocap ()
Simcor ()
Niacin Td ()
NSC-169454 ()
Niacin extended release ()
Acidum nicotinicum ()
Niaspan ()
Nicangin ()
Niacor ()
Niaspan Titration Starter Pack ()
Nicotinate ()
Niaspan Er ()
Nicotinic Acid ()
P&D ID
PD001840
CAS
59-67-6
123574-58-3
101113-41-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1957
Drug Status
nutraceutical
investigational
approved
Drug indication
Vitamin (enzyme co-factor)
Lipid metabolism disorder
Antihyperlipidemic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nicotinic acid (niacin) is a form of vitamin B3 and it is the precursor for NAD and NADP. (GtoPdb)
Cell lines
0
Organisms
2
Compound Sets
30
Cayman Chemical Bioactives
37416
ChEMBL Approved Drugs
CHEMBL573
ChEMBL Drugs
CHEMBL573
Concise Guide to Pharmacology 2017/18
1588
1594
Concise Guide to Pharmacology 2019/20
1588
1594
Concise Guide to Pharmacology 2021/22
1588
1594
Concise Guide to Pharmacology 2023/24
1588
1594
Drug Repurposing Hub
DrugBank
DB00627
DrugBank Approved Drugs
DB00627
DrugCentral
2835
DrugCentral Approved Drugs
2835
DrugMAP
DMQVRZH
DrugMAP Approved Drugs
DMQVRZH
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100390
Guide to Pharmacology
1588
1594
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL573
Mcule NIBR MoA Box Subset
MCULE-3788394698
MedChem Express Bioactive Compound Library
HY-B0143
NCATS Inxight Approved Drugs
2679MF687A
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Niacin(Nicotinic-acid)
TargetMol Bioactive Compound Library
T0879
The Spectrum Collection
External IDs
64
Properties
(calculated by RDKit )
Molecular Weight
123.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
0.78
TPSA
50.19
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Autophagy
Metabolic Enzyme/Protease
Target
VB3
DGAT2, HCAR1, HCAR2, HCAR3, NNMT, QPRT
Endogenous Metabolite
Vitamin
Member status
member
MOA
nicotinic receptor agonist
NAD precursor, vitamin B
Indication
hypertriglyceridemia
Source data