General
Preferred name
NIFEDIPINE
Synonyms
Nifedipine D6 ()
BAY-a-1040 D6 ()
BAY-a-1040 ()
Procardia XL ()
Procardia ()
Adalat ()
nifedipine once daily, Watson ()
Nifedipine (BAY-a-1040) ()
Genalat 20 Ret ()
Coroday MR ()
Coracten SR ()
Afeditab Cr ()
Cardilate MR ()
Hypolar XL 30 ()
Adalat IC ()
Genalat 10 Ret ()
Nifopress MR ()
Adalat LA 30 ()
Adalat Cc ()
Neozipine XL ()
Adalat A.R. ()
BAY A 1040 ()
Angiopine 10 ()
Angiopine 5 ()
Angiopine MR 10 ()
Fortipine LA40 ()
Hypolar Ret 10 ()
Nifedipress MR 10 ()
Slofedipine XL 30 ()
Tensipine MR 20 ()
Kentipine ()
Kentipine MR 20 ()
Adipine MR 10 ()
Unipine XL ()
Adalat Ret ()
Adipine XL ()
Calcilat ()
Nimodrel MR 10 ()
Nifedipine slow release ()
Adalat LA 20 ()
Nifedipinum ()
Kentipine MR 10 ()
Valni XL ()
Nifedipino ()
Adalat LA 60 ()
Nife-Wolff ()
Nifopress Ret ()
Coracten ()
Calchan MR 10 ()
Vasad ()
Adalate LP ()
Valni 20 Ret ()
Angiopine MR 20 ()
Coracten XL ()
Adanif XL ()
Angiopine 40 LA ()
Nifedotard 20 MR ()
Calchan MR 20 ()
Calanif ()
Hypolar Ret 20 ()
Nivaten Ret ()
Adipine MR 20 ()
Nifedipress MR 20 ()
Nifensar Xl ()
Nimodrel MR 20 ()
Tensipine MR 10 ()
Nifelease ()
Nimodrel XL ()
Nifedipine hydrochloride ()
NSC-757242 ()
Slofedipine XL 60 ()
Nifedipine-d6 ()
P&D ID
PD001839
CAS
21829-25-4
101539-70-2
1188266-14-9
Tags
available
drug
Approved by
FDA
First approval
1981
Drug indication
Angina pectoris
premature birth
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION One of the dihydropyridine class of drugs. (GtoPdb)
DESCRIPTION Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.
PRICE 29
DESCRIPTION Potent and selective GluK1 kainate agonist (Tocris Bioactive Compound Library)
DESCRIPTION L-type Ca2+ channel blocker; vasodilator (LOPAC library)
DESCRIPTION Ca2+ channel blocker (L-type) (Tocriscreen Total)
DESCRIPTION Nifedipine blocks voltage gated L-type calcium channels in vascular smooth muscle and myocardial cells. Nifedipine capsules are indicated to treat vasospastic angina and chronic stable angina. Extended release tablets are indicated to treat vasospastic angina, chronic stable angina, and hypertension. (Enamine Bioactive Compounds)
DESCRIPTION Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
7
Compound Sets
39
AdooQ Bioactive Compound Library
A10643
Axon Medchem Screening Library
2068
Cayman Chemical Bioactives
11106
25510
ChEMBL Approved Drugs
CHEMBL193
ChEMBL Drugs
CHEMBL193
Concise Guide to Pharmacology 2017/18
2514
Concise Guide to Pharmacology 2019/20
2514
Concise Guide to Pharmacology 2021/22
2514
Concise Guide to Pharmacology 2023/24
2514
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01115
DrugBank Approved Drugs
DB01115
DrugCentral
1922
DrugCentral Approved Drugs
1922
DrugMAP
DMSVOZT
DrugMAP Approved Drugs
DMSVOZT
DrugMatrix
Enamine Bioactive Compounds
EBC-11141
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101574
Guide to Pharmacology
2514
Ki Database
NIFEDIPINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL193
MedChem Express Bioactive Compound Library
HY-B0284
NCATS Inxight Approved Drugs
I9ZF7L6G2L
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2F78DD2792E0
nursa/index.jsf?doi=10.1621%2FRVZMIO1ZLJ
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Nifedipine(Adalat)
TargetMol Bioactive Compound Library
T1146
The Spectrum Collection
Tocris Bioactive Compound Library
1075
Tocriscreen Total
Withdrawn 2.0
w55
ZINC Tool Compounds
ZINC000085205448
External IDs
60
Properties
(calculated by RDKit )
Molecular Weight
346.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
1
cLogP
2.18
TPSA
107.77
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
L-type
Target
Calcium Channel
CACNA1C, CACNA1D, CACNA1F, CACNA1H, CACNA1S, CACNA2D1, CACNB2, CALM1, GLRA1, GLRA3, GLRB, KCNA1, KCNA5, NR1I2, TRPM3
Ca channel blocker
CAM
Potassium Channel
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Autophagy
Metabolism
Neuroscience
Primary Target
CaV1.x Channels (L-type)
MOA
Blocker
Calcium Channel Blockers
Antioxidants
"Calcium Channel Blockers
Antioxidants"
calcium channel blocker
Member status
member
Indication
vasospastic angina, chronic stable angina
ATC
C08CA05
Toxicity type
cardiovascular
Therapeutic Class
Analgesics
Source data