General
Preferred name
OXYPHENBUTAZONE
Synonyms
Oxazolidin ()
Tanderil Chloramphen ()
Oxiphenbutazone ()
Tanderil ()
Oxyphenbutazone (monohydrate) ()
OXYPHENBUTAZONE ANHYDROUS ()
Crovaril ()
Flogitolo ()
Oxalid ()
RO-04-4410 ()
Rapostan ()
Frabel ()
Californit ()
Suganril ()
NSC-526053 ()
Reozon ()
Visubutina ()
Neo-farmadol ()
Flogoril ()
G-27202 ()
Oxyphenbutazone hydrate ()
Oxifenbutazona ()
Tandearil ()
Phlogont ()
Phlogase ()
NSC-757261 ()
Phlogistol ()
Oxyphenbutazone monohydrate ()
P&D ID
PD001819
CAS
7081-38-1
129-20-4
Tags
available
drug
Approved by
FDA
First approval
1960
Drug indication
Arthritis
rheumatic disease
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Oxyphenbutazone is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis[1][2].
PRICE
82
DESCRIPTION
Oxyphenbutazone is an active metabolite of Phenylbutazone, an orally active COX inhibitor with antimicrobial and anti-inflammatory activity, selectively kills non-replicating Mycobacterium tuberculosis, and induces bone marrow failure.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
20
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
324.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
3.49
TPSA
60.85
Fraction CSP3
0.26
Chiral centers
1.0
Largest ring
6.0
QED
0.86
Structural alerts
1
keto_keto_beta_B(12)
[#6;X4]-1-[#6](=[#8])-[#7]-[#7]-[#6]-1=[#8]
PAINS Family C
Related compounds
Custom attributes
(extracted from source data)
MOA
cyclooxygenase inhibitor
Target
cyclooxygenase
COX
Bacterial
ATC
M01AA03
S01BC02
Toxicity type
hematological
Pathway
Immunology/Inflammation
Microbiology/virology
Neuroscience
Anti-infection
Source data
