General
Preferred name
PHENIRAMINE MALEATE
Synonyms
Daneral ()
Inhiston ()
Trimetose ()
Trimeton ()
NSC-757270 ()
PM-241 ()
Daneral-Sa ()
Antolozine ()
Pheniramine maleate component of visine ()
Prophenpyridamine maleate ()
Pheniramine maleate component of naphcon-a ()
Pheniramine hydrogen maleate ()
Avil ()
Naphcon a ()
Pheniramine maleate component of visine-a ()
Fervex ()
Avil Ret ()
Pheniramine (maleate) ()
P&D ID
PD001806
CAS
132-20-7
86-21-5
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Common cold
First approval
1994
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION H1 histamine receptor antagonist. (LOPAC library)
DESCRIPTION Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
8
Cayman Chemical Bioactives
39473
ChEMBL Approved Drugs
CHEMBL1653
ChEMBL Drugs
CHEMBL1653
LOPAC library
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
pheniramine-maleate
TargetMol Bioactive Compound Library
T0370
The Spectrum Collection
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
356.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
2.88
TPSA
90.73
Fraction CSP3
0.25
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Target
Histamine Receptor
HT
Source data