General
Preferred name
PIROXICAM
Synonyms
CP-16171 ()
Piroxicam (Feldene) ()
CP 16171 ()
PIROXICAM OLAMINE ()
NSC-666076 ()
Feldene P ()
Feldene ()
Brexidol ()
Feldene 20 ()
Flamatrol ()
Piroflam 20 ()
Kentene ()
Larapam ()
Piroflam 10 ()
Pirozip 10 ()
Pirozip 20 ()
CP-16,171 ()
CP-16171-85 ()
CP-16,171-85 ()
CP-1617185 ()
Piroxicam-d3 ()
P&D ID
PD001795
CAS
36322-90-4
942047-64-5
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1982
Drug indication
Pain
osteoarthritis, knee
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic activity.
Drug formulations contain β-cyclodextrin to increase bioavailability eg piroxicam betadex has PubChem CID 54723875. (GtoPdb)
DESCRIPTION Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 ¦ÌM for human monocyte COX-1 and COX-2, respectively.
PRICE 29
DESCRIPTION Cyclooxygenase (COX) inhibitor (LOPAC library)
DESCRIPTION Cyclooxygenase-1 (COX-1) inhibitor (Tocriscreen Total)
DESCRIPTION Piroxicam is an NSAID used to treat the symptoms of osteoarthritis and rheumatoid arthritis. The antiinflammatory effect of Piroxicam may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. (Enamine Bioactive Compounds)
DESCRIPTION Piroxicam (CP-16171) is a non-specific COX inhibitor. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
3
Compound Sets
26
AdooQ Bioactive Compound Library
A10736
Cayman Chemical Bioactives
13368
33248
ChEMBL Approved Drugs
CHEMBL527
ChEMBL Drugs
CHEMBL527
CHEMBL2106953
Drug Repurposing Hub
DrugBank
DB00554
DrugBank Approved Drugs
DB00554
DrugCentral
2210
DrugCentral Approved Drugs
2210
DrugMAP
DMTK234
DrugMAP Approved Drugs
DMTK234
DrugMatrix
Enamine Bioactive Compounds
EBC-26614
Guide to Pharmacology
7273
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL527
MedChem Express Bioactive Compound Library
HY-B0253
NCATS Inxight Approved Drugs
13T4O6VMAM
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Piroxicam(Feldene)
TargetMol Bioactive Compound Library
T0758
The Spectrum Collection
Tocriscreen Total
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
331.06
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
1.58
TPSA
99.6
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
COX
Indication
osteoarthritis, rheumatoid arthritis
Target
PTGS1, PTGS2
MOA
cyclooxygenase inhibitor
Therapeutic Class
Analgesics
Pathway
Immunology/Inflammation
Neuroscience
Source data