General
Preferred name
PIROXICAM
Synonyms
CP-16171 ()
Piroxicam (Feldene) ()
PIROXICAM OLAMINE ()
CP 16171 ()
Piroflam 10 ()
Piroflam 20 ()
Feldene P ()
Pirozip 10 ()
Feldene 20 ()
Kentene ()
NSC-666076 ()
Flamatrol ()
Pirozip 20 ()
CP-16,171 ()
Feldene ()
Brexidol ()
Larapam ()
CP-16,171-85 ()
CP-16171-85 ()
CP-1617185 ()
Piroxicam-d3 ()
P&D ID
PD001795
CAS
36322-90-4
942047-64-5
Tags
drug candidate
natural product
drug
available
Approved by
FDA
First approval
1982
Drug Status
investigational
approved
Drug indication
Analgesic
Anti-Inflammatory,Anti-Inflammatory
Anti-Inflammatory
Pain
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic activity.
Drug formulations contain β-cyclodextrin to increase bioavailability eg piroxicam betadex has PubChem CID 54723875. (GtoPdb)
Drug formulations contain β-cyclodextrin to increase bioavailability eg piroxicam betadex has PubChem CID 54723875. (GtoPdb)
DESCRIPTION
Cyclooxygenase (COX) inhibitor
(LOPAC library)
DESCRIPTION
Cyclooxygenase-1 (COX-1) inhibitor
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
3
Compound Sets
25
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
331.06
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
1.58
TPSA
99.6
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
COX
Pathway
Immunology/Inflammation
Neuroscience
Indication
osteoarthritis, rheumatoid arthritis
Target
PTGS1, PTGS2
MOA
cyclooxygenase inhibitor
Therapeutic Class
Analgesics
Source data