General
Preferred name
PRAZOSIN HYDROCHLORIDE
Synonyms
Prazosin HCl ()
cp-12299-1 ()
Vasoflex ()
Minipress ()
Peripress ()
Prazosin (hydrochloride) ()
Hypovase B.D. ()
Alphavase 0.5 ()
Hypovase ()
Alphavase 1 ()
NSC-292810 ()
Kentovace ()
Alphavase 2 ()
CP-12,299-1 ()
Minipress Xl ()
Alphavase 5 ()
P&D ID
PD001792
CAS
19237-84-4
19216-56-9
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antihypertensive
First approval
1976
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Peripheral alpha1 adrenoceptor antagonist (LOPAC library)
DESCRIPTION alpha1 and alpha2B antagonist. MT3 antagonist (Tocriscreen Plus)
DESCRIPTION beta antagonist (Tocris Bioactive Compound Library)
DESCRIPTION α1 and α2B antagonist. MT3 antagonist (Tocriscreen Total)
Cell lines
0
Organisms
2
Compound Sets
15
AdooQ Bioactive Compound Library
A11914
Axon Medchem Screening Library
2040
Cayman Chemical Bioactives
15023
ChEMBL Approved Drugs
CHEMBL1558
ChEMBL Drugs
CHEMBL1558
EU-OPENSCREEN Bioactive Compound Library
EOS101299
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0193A
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Prazosin-hydrochloride
TargetMol Bioactive Compound Library
T1050
The Spectrum Collection
Tocris Bioactive Compound Library
0623
Tocriscreen Plus
0623
Tocriscreen Total
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
419.14
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
2.21
TPSA
106.95
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
alpha1
Pathway
Neuroscience
Immunology/Inflammation
Membrane Transporter/Ion Channel
GPCR/G protein
Autophagy
Neuronal Signaling
Target
ABCG
Adrenergic Receptor
MRP1
Potassium Channel
a1 antagonist
Primary Target
Adrenergic ?1 Receptors
MOA
Antagonist
Source data