General
Preferred name
PRIMAQUINE PHOSPHATE
Synonyms
Primaquine bisphosphate ()
Primaquine Diphosphate ()
Primaquine (Diphosphate) ()
Primaquine (phosphate) ()
Primaquine (bisphosphate) ()
Primaquine diphosphate ()
WR 2975 ()
Camden ()
NSC-149765 ()
Malquine ()
Primaquini diphosphas ()
P&D ID
PD001788
CAS
90-34-6
63-45-6
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Malaria
First approval
1952
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Primaquine diphosphate is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine diphosphate prevents relapse in vivax and ovale malaria[1].
DESCRIPTION Primaquine is the only generally available anti-malarial that prevents relapse in vivax and ovale malaria, and the only potent gametocytocide in falciparum malaria. (BOC Sciences Bioactive Compounds)
DESCRIPTION Primaquine diphosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria. Primaquine is active against late hepatic stages (hypnozoites, schizonts). (TargetMol Bioactive Compound Library)
Cell lines
10
Organisms
2
Compound Sets
10
Axon Medchem Screening Library
3177
BOC Sciences Bioactive Compounds
primaquine-bisphosphate-cas-63-45-6-74002
Cayman Chemical Bioactives
18223
ChEMBL Approved Drugs
CHEMBL43128
ChEMBL Drugs
CHEMBL43128
MedChem Express Bioactive Compound Library
HY-12651
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
primaquine-diphosphate
TargetMol Bioactive Compound Library
T0850
The Spectrum Collection
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
455.12
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
8
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
0.93
TPSA
215.69
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Parasite
Antimalarial drug
MOA
Antibiotic
Pathway
Microbiology/virology
Anti-infection
Source data