General
Preferred name
PRIMIDONE
Synonyms
Primidonum ()
NCI-C56360 ()
Primaclone ()
Mysoline ()
Resimatil ()
Lepsiral ()
Liskantin ()
NSC-41701 ()
Lepimidin ()
Neurosyn ()
Primidone (CRM) ()
P&D ID
PD001787
CAS
125-33-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1954
Drug Status
approved
vet_approved
Drug indication
Anticonvulsant
Epilepsy
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Primidone is a barbiturate anticonvulsant. Clinical use of primidone has largely been replaced by newer alternatives.
(GtoPdb)
DESCRIPTION
Anticonvulsant
(LOPAC library)
DESCRIPTION
Potentiates GABAA receptor function
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
30
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
218.11
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
0.54
TPSA
58.2
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
ionotropic GABA receptor agonist
GABA Receptor antagonist
Target
Sodium channel alpha subunit
GABA-A receptor
anion channel
nAChR
GABAR
GluR2
Sodium Channel
CHRNA4, CHRNA7, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA2, GRIK2, SCN10A, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN7A, SCN8A, SCN9A
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Indication
seizures
Therapeutic Class
Anticonvulsants
Source data
