General
Preferred name
PROBENECID
Synonyms
Probenecid w/ colchicine ()
Benemid ()
PROBENECID SODIUM ()
probenecid57-66-9 ()
Probenecid (sodium) ()
P-(dipropylsulfamoyl)benzoic acid ()
Probenate ()
Probecid ()
Probenecid component of colbenemid ()
Benuryl ()
Probampicin ()
Probenecid component of proben-c ()
Probalan ()
NSC-18786 ()
Probenecid component of orlynvah ()
Probenecid component of col- ()
Probenecide ()
Probenecidum ()
Probenecid component of probampacin ()
HC 5006 ()
Probenecid-d14 ()
P&D ID
PD001786
CAS
57-66-9
23795-03-1
1189657-87-1
Tags
available
drug
Approved by
FDA
First approval
1951
Drug indication
Hyperuricaemia
Gout
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Probenecid is considered to be the prototypical uricosuric agent. (GtoPdb)
DESCRIPTION Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.
PRICE 29
DESCRIPTION Probenecid sodium is the sodium salt of Probenecid. Probenecid is an effective selective transient receptor potential vanilloid 2 (TRPV2) agonist. Probenecid also inhibits the pannexin 1 channel[1][2][3][4].
DESCRIPTION Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. It is the prototypical uricosuric agent and is primarily used in treating gout and hyperuricemia. Probenecid is also a clinically used broad-spectrum Pannexin1 blocker. I it used to treat gouty arthritis, tophaceous gout, and hyperuricemia. (Enamine Bioactive Compounds)
DESCRIPTION MRP inhibitor (Tocriscreen Plus)
DESCRIPTION Antimalarial; inhibits apoptosis and autophagy (Tocris Bioactive Compound Library)
DESCRIPTION Probenecid (Benemid) is a benzoic acid derivative with antihyperuricemic property. (TargetMol Bioactive Compound Library)
Compound Sets
35
Cayman Chemical Bioactives
14981
26294
26787
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL897
ChEMBL Drugs
CHEMBL897
Concise Guide to Pharmacology 2017/18
4357
Concise Guide to Pharmacology 2019/20
4357
Concise Guide to Pharmacology 2021/22
4357
Concise Guide to Pharmacology 2023/24
4357
Concise Guide to Pharmacology 2025/26
4357
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01032
DrugBank Approved Drugs
DB01032
DrugCentral
2268
DrugCentral Approved Drugs
2268
DrugMAP
DMMFWOJ
DrugMAP Approved Drugs
DMMFWOJ
DrugMatrix
Enamine Bioactive Compounds
EBC-03820
Enamine BioReference Compounds
Guide to Pharmacology
4357
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL897
MedChem Express Bioactive Compound Library
HY-B0545
HY-W404916
NCATS Inxight Approved Drugs
FXB45Q4ZVK
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
probenecid-benemid
TargetMol Bioactive Compound Library
T0457
The Spectrum Collection
Tocris Bioactive Compound Library
4107
Tocriscreen Plus
4107
ZINC Tool Compounds
ZINC000000001982
External IDs
180
Properties
(calculated by RDKit )
Molecular Weight
285.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
1
cLogP
2.2
TPSA
74.68
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
MOA
organic anion transporter inhibitor
Inhibitor
MRP-1 Inhibitors
TRPV2 (Vanilloid VR2 Receptor) Agonists
uricosuric blocker
Target
Solute carrier family 22 member 6
Solute carrier family 22 member 8
Solute carrier family 22 member 11
Bacterial
HIV
TRP Channel
TRPV2
PANX1, SLC22A11, SLC22A6, SLC22A8, SLCO1C1
Influenza Virus
Interleukin Related
Taste Receptor,TRP Channel
Primary Target
Multidrug Transporters
Member status
member
Indication
hyperuricemia, gout
Disease Area
nephrology, rheumatology
Therapeutic Class
Uricosuric Agents
Pathway
Anti-infection
Membrane Transporter/Ion Channel
Neuronal Signaling
Immunology/Inflammation
Microbiology/virology
Proteases/Proteasome
Source data