General
Preferred name
PROBENECID
Synonyms
Probenecid w/ colchicine ()
Benemid ()
PROBENECID SODIUM ()
probenecid57-66-9 ()
Probenate ()
HC 5006 ()
Probecid ()
Probampicin ()
Probenecidum ()
NSC-18786 ()
Probalan ()
Benuryl ()
P-(dipropylsulfamoyl)benzoic acid ()
Probenecid-d14 ()
P&D ID
PD001786
CAS
57-66-9
23795-03-1
1189657-87-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1951
Drug Status
investigational
approved
Drug indication
Gout
Hyperuricaemia
Uricosuric
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Probenecid is considered to be the prototypical uricosuric agent. (GtoPdb)
DESCRIPTION MRP inhibitor (Tocriscreen Plus)
DESCRIPTION Antimalarial; inhibits apoptosis and autophagy (Tocris Bioactive Compound Library)
Compound Sets
32
Cayman Chemical Bioactives
14981
26294
26787
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL897
ChEMBL Drugs
CHEMBL897
Concise Guide to Pharmacology 2017/18
4357
Concise Guide to Pharmacology 2019/20
4357
Concise Guide to Pharmacology 2021/22
4357
Concise Guide to Pharmacology 2023/24
4357
Drug Repurposing Hub
DrugBank
DB01032
DrugBank Approved Drugs
DB01032
DrugCentral
2268
DrugCentral Approved Drugs
2268
DrugMAP
DMMFWOJ
DrugMAP Approved Drugs
DMMFWOJ
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
4357
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL897
MedChem Express Bioactive Compound Library
HY-B0545
NCATS Inxight Approved Drugs
FXB45Q4ZVK
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
probenecid-benemid
TargetMol Bioactive Compound Library
T0457
The Spectrum Collection
Tocris Bioactive Compound Library
4107
Tocriscreen Plus
4107
ZINC Tool Compounds
ZINC000000001982
External IDs
51
Properties
(calculated by RDKit )
Molecular Weight
285.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
1
cLogP
2.2
TPSA
74.68
Fraction CSP3
0.46
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
MOA
organic anion transporter inhibitor
Inhibitor
MRP-1 Inhibitors
TRPV2 (Vanilloid VR2 Receptor) Agonists
uricosuric blocker
Target
Solute carrier family 22 member 6
Solute carrier family 22 member 8
Solute carrier family 22 member 11
TRPV2
PANX1, SLC22A11, SLC22A6, SLC22A8, SLCO1C1
Bacterial
HIV
TRP Channel
Taste Receptor,TRP Channel
Pathway
Membrane Transporter/Ion Channel
Anti-infection
Neuronal Signaling
Primary Target
Multidrug Transporters
Member status
member
Indication
hyperuricemia, gout
Disease Area
nephrology, rheumatology
Therapeutic Class
Uricosuric Agents
Source data