General
Preferred name
PROPYLTHIOURACIL
Synonyms
NSC 6498 ()
6-Propyl-2-thiouracil ()
Pseudocapsaicin ()
NSC 70461 ()
6-n-Propylthiouracil ()
PTU ()
NSC 6498, NSC 70461 ()
Propylthiouracil ()
Thyreostat ii ()
NSC-6498 ()
Propylthiouracile ()
Propiltiouracilo ()
Propacil ()
NSC-70461 ()
Prothyran ()
Propylthiouracil-d5 ()
P&D ID
PD001776
CAS
51-52-5
500-50-5
1189423-94-6
Tags
available
covalent binder
drug
Approved by
FDA
First approval
1947
Drug indication
Thyrotoxicosis
Hyperthyroidism
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Propylthiouracil is a thiouracil-derived drug, which acts as a thyroperoxidase inhibitor.
Propylthiouracil is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). (GtoPdb)
Propylthiouracil is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). (GtoPdb)
DESCRIPTION
Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research[1].
PRICE
29
DESCRIPTION
Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
31
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CovalentInDB
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
53
Molecular Weight
170.05
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
1.38
TPSA
48.65
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Thyroid peroxidase inhibitor
Type 1 deiodinase inhibitor
"Thyroid peroxidase inhibitor
Type 1 deiodinase inhibitor"
Target
Thyroid peroxidase
Type I iodothyronine deiodinase (Type-I 5'-deiodinase) (DIOI) (Type 1 DI) (5DI)
Thyroid peripheral conversion
DIO1, TPO
Thyroid hormone receptor
Peroxidases
Member status
member
Indication
hyperthyroidism, Grave's disease, goiter
Therapeutic Class
Antithyroid Agents
Pathway
Endocrinology/Hormones
Vitamin D Related/Nuclear Receptor
Source data
