General
Preferred name
RESERPINE
Synonyms
Serpalan ()
Serpasil ()
Serpivite ()
Reserpine (hydrochloride) ()
Reserpine component of ser-ap-es ()
Reserpine component of hydrap-es ()
Reserpine component of renese-r ()
Reserpine component of salutensin ()
Apoplon ()
Reserpine component of diutensen-r ()
Reserpine component of naquival ()
Reserpine component of ser-a-gen ()
Reserpine component of dralserp ()
Reserpine component of hydroserpine plus (r-h-h) ()
NSC-59272 ()
Reserpine component of hydromox r ()
Serpate ()
Reserpine component of metatensin ()
Reserpine component of serpasil-apresoline ()
Rau-Sed ()
NSC-237659 ()
Reserpina ()
Sandril ()
Reserpine component of hydralazine hydrochloride-hydrochlorothiazide- ()
Reserpine component of regroton ()
Reserpine component of serpasil-esidrix ()
ENT-50146 ()
Hiserpia ()
Reserpine component of hydropres ()
Reserpine component of unipres ()
Reserpine component of hydro-reserp ()
Reserpine component of demi-regroton ()
Reserpine component of cam-ap-es ()
Reserpinum ()
Serpanray ()
Reserpine component of h.r.-50 ()
APOPLON ()
HISERPIA ()
RAU-SED ()
RESERPINA ()
RESERPINE COMPONENT OF CAM-AP-ES ()
RESERPINE COMPONENT OF DEMI-REGROTON ()
RESERPINE COMPONENT OF DIUTENSEN-R ()
RESERPINE COMPONENT OF DRALSERP ()
RESERPINE COMPONENT OF H.R.-50 ()
RESERPINE COMPONENT OF HYDRALAZINE HYDROCHLORIDE-HYDROCHLOROTHIAZIDE- ()
RESERPINE COMPONENT OF HYDRAP-ES ()
RESERPINE COMPONENT OF HYDRO-RESERP ()
RESERPINE COMPONENT OF HYDROMOX R ()
RESERPINE COMPONENT OF HYDROPRES ()
RESERPINE COMPONENT OF HYDROSERPINE PLUS (R-H-H) ()
RESERPINE COMPONENT OF METATENSIN ()
RESERPINE COMPONENT OF NAQUIVAL ()
RESERPINE COMPONENT OF REGROTON ()
RESERPINE COMPONENT OF RENESE-R ()
RESERPINE COMPONENT OF SALUTENSIN ()
RESERPINE COMPONENT OF SER-A-GEN ()
RESERPINE COMPONENT OF SER-AP-ES ()
RESERPINE COMPONENT OF SERPASIL-APRESOLINE ()
RESERPINE COMPONENT OF SERPASIL-ESIDRIX ()
RESERPINE COMPONENT OF UNIPRES ()
RESERPINUM ()
SANDRIL ()
SERPANRAY ()
SERPATE ()
Reserpine hydrochloride ()
P&D ID
PD001766
CAS
50-55-5
1407-38-1
1263-94-1
16994-56-2
Tags
available
drug
Approved by
FDA
First approval
1960
1955
Drug indication
Hypertension
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Reserpine irreversibly blocks the vesicular monoamine transporter (VMAT; gene symbols SLC18A1 and SLC18A2), to bring about depletion of monoamine neurotransmitters at synapses. (GtoPdb)
PRICE 29
DESCRIPTION Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).
PRICE 29
DESCRIPTION Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).
DESCRIPTION Reserpine hydrochloride ??Serpivite hydrochloride?? is the salt form of Reserpine, an alkaloid that inhibits the uptake of norepinephrine into storage vesicles, leading to depletion of catecholamines and serotonin in central and peripheral axon terminals, with antihypertensive and antipsychotic potential.
DESCRIPTION GABA uptake inhibitor; moderately BGT-1 selective (Tocris Bioactive Compound Library)
DESCRIPTION Inhibits vesicular catecholine and serotonin uptake. (LOPAC library)
DESCRIPTION Inhibitor of vesicular monoamine transport (Tocriscreen Total)
DESCRIPTION Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug. (BOC Sciences Bioactive Compounds)
DESCRIPTION Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. (Enamine Bioactive Compounds)
DESCRIPTION Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
3
Compound Sets
34
BOC Sciences Bioactive Compounds
reserpine-cas-50-55-5-item-84-69890
Cayman Chemical Bioactives
16474
ChEMBL Approved Drugs
CHEMBL772
ChEMBL Drugs
CHEMBL772
Concise Guide to Pharmacology 2017/18
4823
Concise Guide to Pharmacology 2019/20
4823
Concise Guide to Pharmacology 2021/22
4823
Concise Guide to Pharmacology 2023/24
4823
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00206
DrugBank Approved Drugs
DB00206
DrugCentral
2370
DrugCentral Approved Drugs
2370
DrugMAP
DM6VM38
DrugMAP Approved Drugs
DM6VM38
Enamine Bioactive Compounds
EBC-11044
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101211
EUbOPEN Chemogenomics Library
EUB0002702
Guide to Pharmacology
4823
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL772
MedChem Express Bioactive Compound Library
HY-N0480
HY-N0480A
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Reserpine
TargetMol Bioactive Compound Library
T0791
The Spectrum Collection
Tocris Bioactive Compound Library
2742
Tocriscreen Total
ZINC Tool Compounds
ZINC000003938746
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
608.27
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
6
Aromatic Ring Count
3
cLogP
4.17
TPSA
117.78
Fraction CSP3
0.52
Chiral centers
6.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Uptake
Pathway
Autophagy
Immunology/Inflammation
Membrane Transporter/Ion Channel
Primary Target
Vesicular Monoamine Transporters
MOA
Inhibitor
Norepinephrine Uptake Inhibitor
Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors
vesicular monoamine transporter inhibitor
Member status
member
Target
SLC18A1, SLC18A2
Monoamine transporter
VMAT
Bile salt export pump
MRP1
SVAT
Indication
hypertension
Therapeutic Class
Antihypertensive Agents
Recommended Cell Concentration
None
Source data