General
Preferred name
SALICYLIC ACID
Synonyms
Salcolex ()
2-Hydroxybenzoic acid ()
salicylic-acid ()
Salicyclic acid ()
salicylic acid, Orenova ()
Salicylate ()
Ionil-Plus ()
Toepedo ()
Lamivudine related compound salicylic acid ()
Metanium ()
Dr. Scholl's Wart Remover Kit ()
Jadit ()
Duofilm Wart Remover ()
Lamivudine impurity, salicylic acid- ()
Edinburgh ()
Phytex ()
Advanced Pain Relief Com Removers ()
Ionil ()
Clear Away Wart Remover ()
Salicylic Acid Soap ()
Phytocil ()
Freezone ()
Advanced Pain Relief Callus Removers ()
Salicylic acid rs ()
Dr. Scholl's Corn Removers ()
Stri-Dex ()
Compound V ()
Verrugon ()
Gppe Paint ()
Noxacorn ()
Pyralvex ()
NSC-180 ()
Acnisal ()
Thwart ()
Occlusal ()
Duoplant ()
Necol ()
Bazuka ()
K-557 ()
2-Hydroxy-benzoic acid ()
Salactol ()
Posalfilin ()
Duofilm ()
Dr. Scholl's Callus Removers ()
Saligel ()
Wartex ()
Erytex ()
Phiso-Clear ()
Salatac ()
Keralyt ()
FEMA NO. 3985 ()
Compound W ()
Cuplex Verruca ()
Salicylic Acid-d4 ()
P&D ID
PD001758
CAS
69-72-7
63-36-5
78646-17-0
Tags
obsolete probe
natural product
drug
available
First approval
1898
Drug Status
investigational
approved
vet_approved
Drug indication
Keratolytic
Seborrhoeic dermatitis
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Salicylic acid directly irreversibly inhibits COX-1 and COX-2 to decrease conversion of arachidonic acid to precursors of prostaglandins and thromboxanes. Salicylate's use in rheumatic diseases is due to it's analgesic and anti-inflammatory activity. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Salicylic acid allows cells of the epidermis to more readily slough off. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid competitively inhibits oxidation of uridine-5-diphosphoglucose (UDPG) with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of the glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to a phenolic acceptor. Inhibition of mucopoly saccharide synthesis is likely responsible for the slowing of wound healing with salicylates.
DESCRIPTION Chemically, salicylic acid is a monohydroxybenzoic acid, a type of phenolic acid and a beta hydroxy acid. It was oridinally isolated from the inner bark of the willow tree. Clinically, it is an important active metabolite of . (GtoPdb)
Cell lines
0
Organisms
1
Compound Sets
28
Cayman Chemical Bioactives
32991
35418
ChEMBL Approved Drugs
CHEMBL424
ChEMBL Drugs
CHEMBL424
Concise Guide to Pharmacology 2017/18
4306
Concise Guide to Pharmacology 2019/20
4306
Concise Guide to Pharmacology 2021/22
4306
Concise Guide to Pharmacology 2023/24
4306
Drug Repurposing Hub
DrugBank
DB00936
DrugBank Approved Drugs
DB00936
DrugCentral
2416
DrugCentral Approved Drugs
2416
DrugMAP
DM2F8XZ
DrugMAP Approved Drugs
DM2F8XZ
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
4306
JUMP-Target 1 Compound Set
118212070
Ki Database
salicylic acid
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL424
MedChem Express Bioactive Compound Library
HY-B0167
NCATS Inxight Approved Drugs
O414PZ4LPZ
NPC Screening Collection
Obsolete Compounds
salicylate
ReFrame library
Selleckchem Bioactive Compound Library
salicylic-acid
TargetMol Bioactive Compound Library
T0649
The Spectrum Collection
External IDs
73
Properties
(calculated by RDKit )
Molecular Weight
138.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
1.09
TPSA
57.53
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Neuroscience
Apoptosis
Autophagy
Metabolic Enzyme/Protease
Target
COX
AKR1C1, ASIC3, PTGS1, PTGS2
AKR1C1
Endogenous Metabolite
Mitophagy
Indication
acne vulgaris (AV), fever, pain relief
Disease Area
dermatology, endocrinology, neurology/psychiatry
MOA
cyclooxygenase inhibitor, prostanoid receptor antagonist
Therapeutic Class
Antiinflammatory Agents
Source data