General
Preferred name
SALICYLIC ACID
Synonyms
Salcolex ()
2-Hydroxybenzoic acid ()
salicylic-acid ()
Salicyclic acid ()
salicylic acid, Orenova ()
Acnisal ()
Lamivudine related compound salicylic acid ()
Cuplex Verruca ()
Bazuka ()
Gppe Paint ()
Erytex ()
Noxacorn ()
Phiso-Clear ()
NSC-180 ()
Jadit ()
Freezone ()
Phytex ()
Verrugon ()
FEMA NO. 3985 ()
Occlusal ()
Necol ()
Pyralvex ()
Salatac ()
Salicylic acid rs ()
K-557 ()
Lamivudine impurity, salicylic acid- ()
Phytocil ()
Compound W ()
Posalfilin ()
Edinburgh ()
Compound V ()
Dr. scholl's callus removers ()
Metanium ()
Toepedo ()
Wartex ()
Duofilm ()
Keralyt ()
Thwart ()
Salactol ()
Salicylic Acid-d4 ()
Salicylate ()
P&D ID
PD001758
CAS
69-72-7
63-36-5
78646-17-0
Tags
available
drug
natural product
obsolete probe
First approval
1898
Drug indication
Eye inflammation
Seborrhoeic dermatitis
Drug Status
vet_approved
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Salicylic acid directly irreversibly inhibits COX-1 and COX-2 to decrease conversion of arachidonic acid to precursors of prostaglandins and thromboxanes. Salicylate's use in rheumatic diseases is due to it's analgesic and anti-inflammatory activity. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Salicylic acid allows cells of the epidermis to more readily slough off. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid competitively inhibits oxidation of uridine-5-diphosphoglucose (UDPG) with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of the glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to a phenolic acceptor. Inhibition of mucopoly saccharide synthesis is likely responsible for the slowing of wound healing with salicylates.
DESCRIPTION
Chemically, salicylic acid is a monohydroxybenzoic acid, a type of phenolic acid and a beta hydroxy acid. It was originally isolated from the inner bark of the willow tree. Clinically, it is an important active metabolite of .
(GtoPdb)
DESCRIPTION
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-¦ÊB) activation[1].
PRICE
29
DESCRIPTION
Salicylic acid directly irreversibly inhibits COX-1 and COX-2 to decrease conversion of arachidonic acid to precursors of prostaglandins and thromboxanes. Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
(Enamine Bioactive Compounds)
DESCRIPTION
Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
29
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
JUMP-Target 1 Compound Set
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Obsolete Compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
78
Molecular Weight
138.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
1.09
TPSA
57.53
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Autophagy
Immunology/Inflammation
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Indication
acne vulgaris (AV), fever, pain relief
Disease Area
dermatology, endocrinology, neurology/psychiatry
Target
AKR1C1, ASIC3, PTGS1, PTGS2
AKR1C1
COX
Endogenous Metabolite
Mitophagy
MOA
cyclooxygenase inhibitor, prostanoid receptor antagonist
Therapeutic Class
Antiinflammatory Agents
Source data
