General
Preferred name
SULFAMETHAZINE
Synonyms
SULFAMERAZINE ()
Sulfadimerazine ()
sulfadimidine ()
Sulfamethazine sodium salt ()
Sulfamethazine ()
Sulfamethazine (sodium) ()
Sulfadimidine (sodium) ()
Sulfadimerazine (sodium) ()
Sulfadimidine,Sulfadimerazine ()
Sulfadimethyldiazine Sodium Salt ()
Sulfamezathine ('S-Mez') ()
NSC-67457 ()
Sulfamethazine (Trisulfapyrimidines) ()
Sulfadimethylpyrimidine ()
Sulfamezathine ()
Sulfamidine ()
Sulfadimidinum ()
Smz-Med 454 ()
NSC-683529 ()
BN-2409 ()
Sulfamethazine-d4 ()
P&D ID
PD001748
CAS
57-68-1
1981-58-4
1020719-82-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1949
Drug Status
investigational
withdrawn
approved
vet_approved
Drug indication
Bacterial infection
Antibacterial
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
60
Molecular Weight
278.08
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.48
TPSA
97.97
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
antibiotic
Bacterial
MOA
Antibiotic
PABA antagonist
Indication
enteritis
ATC
J01EB03
Therapeutic Class
Antiinfective Agents
Source data
