General
Preferred name
SULFAMETHOXAZOLE
Synonyms
STX 608 ()
Ro 4-2130 ()
Sulfamethoxazolum ()
Sulphamethoxazole ()
Sulfamethoxazole sodium ()
RO-4-2130 ()
Sinomin ()
Gantanol ()
Suphamethoxazole ()
STX-608 ()
Gantanol-Ds ()
Urobak ()
Acetylsulfamethoxazole ()
NSC-147832 ()
Sulfamethoxazole-d4 ()
P&D ID
PD001746
CAS
723-46-6
129378-89-8
1020719-86-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1973
Drug Status
approved
Drug indication
Antibacterial
Bacterial infection
Infection of P. falciparum
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sulfamethoxazole is a sulfonamide antibacterial that has bacteriostatic activity. It inhibits the bacterial dihydropteroate synthase pathway which generates the folic acid that is essential for bacterial growth. It is active against Gram-negative and Gram-positive bacteria including Listeria monocytogenes and E. coli.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
253.05
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.37
TPSA
98.22
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Anti-infection
Target
DHPS
FolC
antibiotic
Bacterial
Antibiotics,Bacterial
Indication
pneumonia, enteritis, urinary tract infections
Disease Area
infectious disease, gastroenterology
MOA
PABA antagonist
Therapeutic Class
Antiinfective Agents
Source data
