General
Preferred name
SULFAMETHOXAZOLE
Synonyms
Ro 4-2130 ()
STX 608 ()
Sulfamethoxazolum ()
Sulfamethoxazole component of cotrim ()
Sulfamethoxazole component of bactrim ds ()
Sulfamethoxazole component of septra ()
STX-608 ()
Sulfamethoxazole component of sulfatrim ()
Sulfamethoxazole component of bactrim ()
Acetylsulfamethoxazole ()
Sulfamethoxazole component of azo gantanol ()
Sulfamethoxazole component of sulfamethoprim ()
Sulfamethoxazole sodium ()
Sulfamethoxazole component of uroplus ()
Gantanol ()
Gantanol-Ds ()
Sulfamethoxazole component of bactrim pediatric ()
Suphamethoxazole ()
Sulfamethoxazole component of cotrim d.s. ()
Sulfamethoxazole component of co-trimethoxazole ()
Sulphamethoxazole ()
Sinomin ()
Urobak ()
RO-4-2130 ()
NSC-147832 ()
Sulfamethoxazole component of sulmeprim ()
Sulfametoxazol ()
Sulfamethoxazole-d4 ()
P&D ID
PD001746
CAS
723-46-6
129378-89-8
1020719-86-1
Tags
available
drug
Approved by
FDA
First approval
1973
Drug indication
infection
Infection of P. falciparum
Bacterial infection
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sulfamethoxazole is a sulfonamide antibacterial that has bacteriostatic activity. It inhibits the bacterial dihydropteroate synthase pathway which generates the folic acid that is essential for bacterial growth. It is active against Gram-negative and Gram-positive bacteria including Listeria monocytogenes and E. coli.
(GtoPdb)
DESCRIPTION
Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis[1][2][3].
PRICE
29
DESCRIPTION
Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. In combination with trimethoprim it has been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.
(Enamine Bioactive Compounds)
DESCRIPTION
Sulfamethoxazole (STX 608) is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification of sulfamethoxazole is Sulfonamides.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
23
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
253.05
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.37
TPSA
98.22
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
pneumonia, enteritis, urinary tract infections
Disease Area
infectious disease, gastroenterology
MOA
PABA antagonist
Pathway
Autophagy
Microbiology/virology
Anti-infection
Target
antibiotic
Bacterial
Antibiotics,Bacterial
DHPS
Therapeutic Class
Antiinfective Agents
Source data
