General
Preferred name
SULFAPYRIDINE
Synonyms
4-amino-N-(pyridin-2-yl)benzene-1-sulfonamide ()
SULFAPYRIDINE SODIUM ()
Piridazol ()
Eubasin ()
Coccoclase ()
Sulfanilamidopyridine ()
Concord 693 ()
NSC-4753 ()
Dagenan ()
NSC-41791 ()
Sulfapiridina ()
Sodium sulfapyridine ()
Sulfapyridine sodium salt monohydrate ()
P&D ID
PD001745
CAS
144-83-2
127-57-1
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1939
Drug indication
Dermatitis herpetiformis
bacterial disease
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Sulfapyridine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid by means of processing the substrate para-aminobenzoic acid (PABA). Dihydropteroate synthetase activity is vital in the synthesis of folate, and folate is required for cells to make nucleic acids, such as DNA or RNA. So if DNA molecules cannot be built, the cell cannot divide.;
DESCRIPTION
Sulfapyridine is a sulfonamide compound that was used clinically as an antibacterial agent but is now used principally as an anti-inflammatory drug.
(GtoPdb)
DESCRIPTION
Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 ¦ÌM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities[1][2][3].
PRICE
29
DESCRIPTION
Sulfapyridine (2-Sulfapyridine) is a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine.
DESCRIPTION
Sulfapyridine is a sulfonamide antibiotic with antibacterial and anti-inflammatory activities. Sulfapyridine has previously been used in the treatment of dermatological conditions and ulcerative colitis.
(Enamine Bioactive Compounds)
DESCRIPTION
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory); PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
249.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.46
TPSA
85.08
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Autophagy
PABA antagonist
Indication
gram-negative bacterial infections, gram-positive bacterial infections
ATC
J01EB04
Target
antibiotic
Bacterial
Therapeutic Class
Dermatologic Agents
Pathway
Anti-infection
Source data
