General
Preferred name
SULFATHIAZOLE
Synonyms
SULFACETAMIDE ()
2-Sulfanilamidothiazole ()
Sulfathiazole component of vagilia ()
NSC-683531 ()
Sulfatiazol ()
Sulfathiazole (triple sulfa) ()
Sulfathiazole component of trysul ()
Sulfathiazole component of gyne-sulf ()
Thiazamide ()
NSC-31812 ()
Triple sulfa (sulfathiazole) ()
Sulfathiazole component of sultrin ()
Sulfathiazole (triple sulfa) component of sultrin ()
Sulfathiazol ()
P&D ID
PD001743
CAS
72-14-0
158269-46-6
Tags
available
drug
Approved by
FDA
First approval
1945
Drug Status
vet_approved
approved
withdrawn
Max Phase
4.0
Drug indication
bacterial disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sulfathiazole is a sulfonamide antibacterial compound .
(GtoPdb)
DESCRIPTION
Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3¦Â-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish[1][2][3].
PRICE
29
DESCRIPTION
Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug. It can be mainly used for the treatment of digestive tract, respiratory tract infections, mastitis, endometritis and other diseases caused by sensitive bacteria in domestic animals, and it can also be used for toxoplasma infection.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Sulfathiazole is a short-acting sulfa drug. Sulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle.
(Enamine Bioactive Compounds)
DESCRIPTION
Sulfathiazole (2-Sulfanilamidothiazole), an organosulfur compound, has been served as a short-acting sulfa medicine.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
21
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
255.01
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.53
TPSA
85.08
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Microbiology/virology
Anti-infection
Indication
gram-negative bacterial infections, gram-positive bacterial infections
MOA
dihydropteroate synthase inhibitor
ATC
D06BA02
J01EB07
Toxicity type
hepatic
Target
antibiotic
Bacterial
DHPS
Source data
