General
Preferred name
THIORIDAZINE HYDROCHLORIDE
Synonyms
Mellaril ()
Aldazine ()
Thioridazine (HCl) ()
Thioridazine HCl ()
Thioridazine (hydrochloride) ()
Aldazine, Mellaril ()
Sonapax ()
Thioridazine Hydrochloride Intensol ()
NSC-186060 ()
P&D ID
PD001731
CAS
130-61-0
107388-89-6
50-52-2
Tags
available
drug
nuisance
Drug Status
approved
withdrawn
Max Phase
4.0
First approval
1962
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].
DESCRIPTION
Thioridazine hydrochloride binds to dopamine D2, histamine H1, M3 muscarinic, and alpha1-adrenergic receptor. Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis.
(Enamine Bioactive Compounds)
DESCRIPTION
Dopamine receptor antagonist; Ca2+ channel antagonist; antipsychotic
(LOPAC library)
DESCRIPTION
Thioridazine hydrochloride is a dopamine receptor antagonist displaying antipsychotic activity. Thioridazine induces apoptosis via targeting the PI 3-K/Akt/mTOR/p70 S6K pathway, and induces G1 cell cycle arrest. Thioridazine exhibits anticancer activity in cervical, endometrial and breast cancer cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
(TargetMol Bioactive Compound Library)
DESCRIPTION
H1 antagonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
19
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Nuisance compounds in cellular assays
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
406.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
6.31
TPSA
6.48
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
6.0
QED
0.55
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D1/D2
Primary Target
Non-selective Dopamine
MOA
Antagonist
Pathway
Apoptosis
Autophagy
GPCR/G protein
Membrane Transporter/Ion Channel
Microbiology/virology
Neuroscience
Anti-infection
Neuronal Signaling
Target
MALT1 inhibitor
DA antag.
5-HT Receptor
Bacterial
Dopamine Receptor
5-HT
Adrenergic Receptor
dopamine
Potassium Channel
Source data
