General
Preferred name
BROXYQUINOLINE
Synonyms
Broxiquinolina ()
Dibromohydroxyquinoline ()
5,7-Dibromo-8-hydroxyquinoline ()
NSC-1810 ()
Starogyn ()
P&D ID
PD001714
CAS
521-74-4
22307-80-8
Tags
available
drug
Drug Status
approved
withdrawn
experimental
Max Phase
4.0
Drug indication
amebiasis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Broxyquinoline (Dibromohydroxyquinoline) is an effective inhibitor of severe fever with thrombocytopenia syndrome virus (SFTSV) with an IC50 of 5.8 ¦ÌM. Additionally, Broxyquinoline is an inhibitor of CpACBP1 with an IC50 of 64.9 ¦ÌM. CpACBP1 is a fatty acyl-CoA binding protein of Cryptosporidium parvum, thus Broxyquinoline has the potential to inhibit parasite growth. Broxyquinoline shows promise for research in the field of infectious diseases[1][2].
PRICE
29
DESCRIPTION
Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Broxyquinoline is an anti-infective agent. It exerts activity against fungi and protozoa. Broxyquinoline has been used in the treatment of diarrhoeas of different aetiology. Broxyquinoline is able to promote neovascularization.
(Enamine Bioactive Compounds)
DESCRIPTION
Broxyquinoline (5,7-Dibromo-8-hydroxyquinoline) is an antiprotozoal agent, and it can release oxygen free radicals from the water in mucous membranes.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
300.87
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
3.47
TPSA
33.12
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Parasite
Influenza Virus
MOA
antiprotozoal agent
Pathway
Microbiology/virology
Anti-infection
Source data
